Impact of Sarcopenia on Clinical Outcomes in a Cohort of Caucasian Active Crohn’s Disease Patients Undergoing Multidetector CT-Enterography
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sarcopenia, Nutritional Status, and Body Composition Assessment
2.2. CT Protocol
2.3. Image Analysis
2.4. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. Clinical Outcomes
3.3. Assessment of Body Composition Measures and Association with Clinical Parameters
3.4. Predictors of Sarcopenia
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total (n = 63) | |
---|---|
Age | 44.2 ± 17.0 |
Sex | |
Male | 34 (54.0) |
Female | 29 (46.0) |
BMI (kg/m2) | 21.2 ± 3.6 |
SMI (cm2/m2) | 43.6 ± 9.1 |
SFA (cm2) | 111.8 (91.6) |
Sarcopenic patients | 43 (68.3) |
VFA (cm2) | 57.0 ± 35.0 |
VFA/SFA | 0.62 ± 0.58 |
Disease duration (months) | 140.0 ± 106.5 |
CD Montreal disease localization | |
Ileal | 13 (20.6) |
Colonic | 3 (4.8) |
Ileo-colonic | 46 (73.0) |
Isolated upper-GI | 1 (1.6) |
CD Montreal disease behavior | |
Inflammatory | 2 (3.2) |
Stricturing | 36 (57.1) |
Penetrating | 25 (39.7) |
Perianal disease | 15 (23.8) |
HBI | 7.8 ± 1.7 |
SES-CD | 7.8 ± 5.9 |
BWT (mm) | 7.0 ± 2.2 |
CDE (cm) | 17.8 ± 14.6 |
Extraintestinal manifestations | 13 (20.6) |
Musculoskeletal manifestations | 11 (17.5) |
Cutaneous manifestations | 1 (1.6) |
Ocular Manifestations | 1 (1.6) |
Baseline anti-TNF-α therapy | 18 (28.6) |
Baseline CCS therapy | 15 (23.8) |
Baseline ISS therapy | 14 (22.2) |
Previous anti-TNF-α therapy | 26 (41.3) |
CRP (mg/L) | 2.9 ± 4.0 |
FC (μg/g) | 302.7 ± 163.4 |
Serum albumin (g/dL) | 3.6 ± 0.6 |
Patients with Sarcopenia (n = 43) | Patients without Sarcopenia (n = 20) | p-Value | |
---|---|---|---|
BMI (kg/m2) | 20.3 ± 3.1 | 23.3 ± 3.8 | 0.002 |
SFA (cm2) | 94.1 ± 90.4 | 149.9 ± 84.2 | 0.009 |
VFA (cm2) | 54.0 ± 63.1 | 63.4 ± 62.7 | 0.54 |
VFA/SFA ratio | 0.7 ± 0.6 | 0.4 ± 0.4 | 0.04 |
Age | 45.6 ± 18.0 | 41.1 ± 14.8 | 0.49 |
CRP (mg/L) | 2.91 ± 4.1 | 2.98 ± 3.8 | 0.54 |
Serum albumin (g/L) | 3.49 ± 0.6 | 3.88 ± 0.5 | 0.029 |
FC (μg/g) | 334.66 ± 167.2 | 238.95 ± 138.7 | 0.03 |
Female gender | 18 (41.7) | 11 (55.0) | 0.33 |
EIM | 12 (27.9) | 1 (5.0) | 0.04 |
Baseline anti-TNF-α therapy | 10 (23.2) | 8 (40.0) | 0.17 |
Baseline CCS therapy | 8 (18.6) | 7 (35.0) | 0.15 |
Baseline ISS therapy | 9 (20.9) | 5 (25.0) | 0.72 |
Previous anti-TNF-α therapy | 20 (46.5) | 6 (30.0) | 0.21 |
Need for surgery | 21 (48.8) | 12 (60.0) | 0.41 |
Infectious events | 18 (41.9) | 3 (15.0) | 0.03 |
Low respiratory tract | 6 (13.9) | 1 (5.0) | |
PICC-related | 8 (18.6) | 0 | |
Urinary tract | 1 (2.3) | 1 (5.0) | |
Herpesvirus-related | 2 (4.6) | 1 (5.0) | |
Gynaecologic | 1 (2.3) | 0 |
95% C.I. per EXP(B) | ||||||
---|---|---|---|---|---|---|
Estimated Coefficient | Standard Error | p-Value | Exp(B) | Lower Limit | Upper Limit | |
Body Mass Index | −0.309 | 0.122 | 0.011 | 0.734 | 0.578 | 0.932 |
EIM | 2.957 | 1.479 | 0.046 | 19.233 | 1.059 | 349.139 |
Constant | 6.855 | 2.591 | 0.008 | 948.241 |
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Nardone, O.M.; Ponsiglione, A.; de Sire, R.; Calabrese, G.; Liuzzi, R.; Testa, A.; Guarino, A.D.; Olmo, O.; Rispo, A.; Camera, L.; et al. Impact of Sarcopenia on Clinical Outcomes in a Cohort of Caucasian Active Crohn’s Disease Patients Undergoing Multidetector CT-Enterography. Nutrients 2022, 14, 3460. https://doi.org/10.3390/nu14173460
Nardone OM, Ponsiglione A, de Sire R, Calabrese G, Liuzzi R, Testa A, Guarino AD, Olmo O, Rispo A, Camera L, et al. Impact of Sarcopenia on Clinical Outcomes in a Cohort of Caucasian Active Crohn’s Disease Patients Undergoing Multidetector CT-Enterography. Nutrients. 2022; 14(17):3460. https://doi.org/10.3390/nu14173460
Chicago/Turabian StyleNardone, Olga Maria, Andrea Ponsiglione, Roberto de Sire, Giulio Calabrese, Raffaele Liuzzi, Anna Testa, Alessia Dalila Guarino, Oriana Olmo, Antonio Rispo, Luigi Camera, and et al. 2022. "Impact of Sarcopenia on Clinical Outcomes in a Cohort of Caucasian Active Crohn’s Disease Patients Undergoing Multidetector CT-Enterography" Nutrients 14, no. 17: 3460. https://doi.org/10.3390/nu14173460