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Article

Serum Vitamin D Concentrations, Time to Pregnancy, and Pregnancy Outcomes among Preconception Couples: A Cohort Study in Shanghai, China

1
School of Public Health, National Health Commission Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China
2
Vital Statistics Department, Songjiang District Center for Disease Control and Prevention, Shanghai 201600, China
3
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
4
Shanghai Jiading Maternal and Child Health Care Hospital, Shanghai 201812, China
*
Author to whom correspondence should be addressed.
Academic Editor: Bruce W. Hollis
Nutrients 2022, 14(15), 3058; https://doi.org/10.3390/nu14153058
Received: 3 July 2022 / Revised: 20 July 2022 / Accepted: 21 July 2022 / Published: 26 July 2022
(This article belongs to the Section Nutrition and Public Health)
Background: The role of vitamin D in reproductive health is still unclear. This study aimed to assess the effect of serum 25-hydroxyvitamin D (25(OH)D), among preconception couples, on fecundity, and the associations between 25(OH)D concentrations before and during pregnancy, and pregnancy outcomes. Methods: 200 preconception couples attempting to conceive were recruited and were followed-up until childbirth. Time to pregnancy was collected via telephone every two months or obtained via a questionnaire during pregnancy. Blood samples were collected to measure serum 25(OH)D levels from both partners at enrollment and from women during the second and third trimester of pregnancy. Results: Couples had higher conception rates within six months (adjusted odds ratio (aOR): 3.72, 95% CI: 1.16, 11.9) and reduced time to pregnancy (adjusted fecundability ratio (aFR): 1.50, 95% CI: 1.01, 2.23) if male partners had sufficient 25(OH)D compared with insufficient 25(OH)D. Compared to pregnant women with insufficient 25(OH)D in the third trimester of pregnancy, sufficient 25(OH)D was associated with reduced odds of anemia (OR: 0.22, 95% CI: 0.06, 0.82), longer gestational age (β: 0.53, 95% CI: 0.04, 1.01) and newborns’ higher ponderal index (β: 0.10, 95% CI: 0.01, 0.19). Conclusions: Sufficient serum 25(OH)D levels among preconception men or during pregnancy were associated with better reproductive health. View Full-Text
Keywords: vitamin D; 25-hydroxyvitamin D; conception; time to pregnancy; pregnancy outcomes vitamin D; 25-hydroxyvitamin D; conception; time to pregnancy; pregnancy outcomes
MDPI and ACS Style

Zhang, Y.; Jukic, A.M.Z.; Song, H.; Zhang, L.; Yang, F.; Wu, S.; Yin, D.; Jiang, H. Serum Vitamin D Concentrations, Time to Pregnancy, and Pregnancy Outcomes among Preconception Couples: A Cohort Study in Shanghai, China. Nutrients 2022, 14, 3058. https://doi.org/10.3390/nu14153058

AMA Style

Zhang Y, Jukic AMZ, Song H, Zhang L, Yang F, Wu S, Yin D, Jiang H. Serum Vitamin D Concentrations, Time to Pregnancy, and Pregnancy Outcomes among Preconception Couples: A Cohort Study in Shanghai, China. Nutrients. 2022; 14(15):3058. https://doi.org/10.3390/nu14153058

Chicago/Turabian Style

Zhang, Yu, Anne Marie Z. Jukic, Heqing Song, Lifeng Zhang, Fengyun Yang, Shoule Wu, Dongxiao Yin, and Hong Jiang. 2022. "Serum Vitamin D Concentrations, Time to Pregnancy, and Pregnancy Outcomes among Preconception Couples: A Cohort Study in Shanghai, China" Nutrients 14, no. 15: 3058. https://doi.org/10.3390/nu14153058

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