Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin—A Randomized Double-Blind Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Study Design
2.3. Experimental Procedure
2.3.1. Assessment of Skin Condition Parameters
Assessment of Transepidermal Hydration of the Skin (CORN)
Assessment of Skin Lubrication (Sebum)
Evaluation of Transepidermal Water Loss (TEWL)
2.3.2. Weight and BMI Measurements
2.4. Statistical Methods
3. Results
3.1. Evaluation of CORN, TEWL and Sebum Parameters before and after the Intervention
3.2. Assessment of Anthropometric Parameters before and after Intervention
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Analyzed Parameters | Isotretinoin (I) n = 25 | Isotretinoin with Evening Primrose Oil (IOW) n = 25 | |||||||
---|---|---|---|---|---|---|---|---|---|
Sex of Respondents | Women n, % | Men n, % | Women n, % | Men n, % | p (between Groups) | ||||
17; 68% | 8; 32% | 16; 64% | 9; 36% | 0.7650 | |||||
Severity of acne before the study | No change n; % | Light n; % | Medium n; % | Hard n; % | No change n; % | Light n; % | Medium n; % | Hard n; % | |
0; 0% | 0; 0% | 13; 52% | 12; 48% | 0; 0% | 0; 0% | 13; 52% | 12; 48% | 1.000 | |
Severity of acne after the study | No change n; % | Light n; % | Medium n; % | Hard n; % | No change n; % | Light n; % | Medium n; % | Hard n; % | |
23; 92% | 2; 8% | 0; 0% | 0; 0% | 24; 96% | 1; 4% | 0; 0% | 0; 0% | 0.5520 |
Analyzed Parameters | Total Researched n = 50 | Isotretinoin (I) n = 25 | Isotretinoin with Evening Primrose Oil (IOW) n = 25 | p | |||||
---|---|---|---|---|---|---|---|---|---|
X ± SD | Me ± Q | Min | Max | X ± SD | Me ± Q | X ± SD | Me ± Q | ||
Skin Condition Parameters | |||||||||
CORN arbitrary unit | 50.5 ± 32.7 | 44.1 ± 11.3 | 6.70 | 391 | 58.9 ± 32.4 | 46.4 ± 10.8 | 41.1 ± 16.2 | 42.0 ± 9.70 | 0.367 |
TEWL (g/m2/h) | 20.2 ± 13.7 | 16.0 ± 6.05 | 6.00 | 71.3 | 22.2 ± 16.5 | 15.7 ± 9.10 | 18.1 ± 10.0 | 17.1 ± 3.20 | 0.786 |
Sebum (ug/cm2) | 92.0 ± 68.5 | 55.8 ± 30.5 | 0.00 | 383 | 87.8 ± 54.3 | 65.0 ± 34.5 | 96.2 ± 64.2 | 42.0 ± 30.8 | 0.705 |
Anthropometric parameters | |||||||||
Body height (cm) | 171 ± 5.79 | 169 ± 5.50 | 163 | 183 | 170 ± 5.79 | 169 ± 5.50 | 171 ± 5.79 | 169 ± 5.50 | 0.231 |
Body weight (kg) | 65.0 ± 7.53 | 62.5 ± 4.50 | 55.0 | 86.0 | 64.6 ± 6.61 | 63.0 ± 4.00 | 65.4 ± 8.46 | 62.0 ± 5.00 | 0.953 |
BMI (kg/m2) | 22.2 ± 1.42 | 22.0 ± 0.86 | 20.2 | 27.8 | 22.3 ± 1.15 | 22.3 ± 0.39 | 22.1 ± 1.67 | 21.8 ± 1.12 | 0.367 |
Analyzed Parameters | Isotretinoin (I) n = 25 | Wil coxon Test | Isotretinoin with Evening Primrose Oil (IOW) n = 25 | Wilcoxon Test p | U Mann–Whitney Test (Between Groups) p | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Before Treatment | After 9 Months of Treatment | Δ | Before Treatment | After 9 Months of Treatment | Δ | ||||||
Me ± Q | Me ± Q | Me ± Q | Me ± Q | Me ± Q | Me ± Q | Before Treatment | After Treatment | Δ Before and after Treatment | |||
Skin Condition Parameters | |||||||||||
CORN arbitrary unit | 46.4 ± 10.8 | 39.8 ± 12.4 | −10.5 ± 38.0 | 0.015 | 42.0 ± 9.70 | 50.9 ± 10.4 | 8.70 ± 17.6 | 0.017 | 0.367 | 0.190 | 0.002 |
TEWL (g/m2/h) | 15.7 ± 9.10 | 12.0 ± 6.10 | −6.80 ± 14.7 | 0.004 | 17.1 ± 3.20 | 11.5 ± 2.75 | −5.80 ± 10.4 | 0.001 | 0.786 | 0.760 | 0.946 |
Sebum (ug/cm2) | 65.0 ± 34.5 | 14.0 ± 24.0 | −59.4 ± 73.8 | <0.001 | 42.0 ± 30.8 | 5.00 ± 11.5 | −79.8 ± 102 | <0.001 | 0.705 | 0.110 | 0.554 |
Analyzed Parameters | Isotretinoin (I) n = 25 | Wilcoxon Test p | Isotretinoin with Evening Primrose oil (IOW) n = 25 | Wilcoxon Test p | U Mann–Whitney Test (Between Grups) p | ||||
---|---|---|---|---|---|---|---|---|---|
Before Treatment | After 9 Months of Treatment | Δ | Before Treatment | After 9 Months of Treatment | Δ | ||||
Me ± Q | Me ± Q | Me ± Q | Me ± Q | Me ± Q | Me ± Q | ||||
Body weight (kg) | 63.0 ± 4.00 | 61.0 ± 4.00 | −2.00 ± 0.00 | <0.001 | 62.0 ± 5.00 | 60.0 ± 5.00 | −2.00 ± 0.00 | <0.001 | 0.5250 |
BMI (kg/m2) | 22.3 ± 0.39 | 21.3 ± 0.49 | −0.72 ± 0.05 | <0.001 | 21.8 ± 1.12 | 21.2 ± 1.11 | −0.71 ± 0.05 | <0.001 | 0.6686 |
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Kaźmierska, A.; Bolesławska, I.; Polańska, A.; Dańczak-Pazdrowska, A.; Jagielski, P.; Drzymała-Czyż, S.; Adamski, Z.; Przysławski, J. Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin—A Randomized Double-Blind Trial. Nutrients 2022, 14, 2980. https://doi.org/10.3390/nu14142980
Kaźmierska A, Bolesławska I, Polańska A, Dańczak-Pazdrowska A, Jagielski P, Drzymała-Czyż S, Adamski Z, Przysławski J. Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin—A Randomized Double-Blind Trial. Nutrients. 2022; 14(14):2980. https://doi.org/10.3390/nu14142980
Chicago/Turabian StyleKaźmierska, Agnieszka, Izabela Bolesławska, Adriana Polańska, Aleksandra Dańczak-Pazdrowska, Paweł Jagielski, Sławomira Drzymała-Czyż, Zygmunt Adamski, and Juliusz Przysławski. 2022. "Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin—A Randomized Double-Blind Trial" Nutrients 14, no. 14: 2980. https://doi.org/10.3390/nu14142980
APA StyleKaźmierska, A., Bolesławska, I., Polańska, A., Dańczak-Pazdrowska, A., Jagielski, P., Drzymała-Czyż, S., Adamski, Z., & Przysławski, J. (2022). Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin—A Randomized Double-Blind Trial. Nutrients, 14(14), 2980. https://doi.org/10.3390/nu14142980