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Article

IQ Was Not Improved by Post-Discharge Fortification of Breastmilk in Very Preterm Infants

1
Hans Christian Andersen Children’s Hospital, Odense University Hospital, 5000 Odense, Denmark
2
Department of Paediatrics, Holbaek Hospital, 4300 Holbaek, Denmark
3
Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark
*
Author to whom correspondence should be addressed.
Academic Editors: Ferdinand Haschke and Nadja Haiden
Nutrients 2022, 14(13), 2709; https://doi.org/10.3390/nu14132709
Received: 16 May 2022 / Revised: 26 June 2022 / Accepted: 28 June 2022 / Published: 29 June 2022
(1) Very preterm infants are at increased risk of cognitive deficits, motor impairments, and behavioural problems. Studies have tied insufficient nutrition and growth to an increased risk of neurodevelopmental impairment; (2) Methods: Follow-up study on cognitive and neuropsychological development at 6 years corrected age (CA) in 214 very preterm infants, including 141 breastfed infants randomised to mother’s own milk (MOM) with (F-MOM) or without (U-MOM) fortification and 73 infants fed a preterm formula (PF-group), from shortly before discharge to 4 months CA. Infants with serious congenital anomalies or major neonatal morbidities were excluded prior to intervention. The Wechsler Intelligence Scale for Children IV was used for cognitive testing, and the children’s parents completed the Five to Fifteen Questionnaire (FTF); (3) Results: Post-discharge fortification of MOM did not improve either full-scale intelligence quotient (FSIQ) with a median of 104 vs. 105.5 (p = 0.29), subdomain scores, or any domain score on the FTF questionnaire. Compared to the PF group, the MOM group had significantly better verbal comprehension score with a median of 110 vs. 106 (p = 0.03) and significantly better motor skills scores on the FTF questionnaire (p = 0.01); (4) Conclusions: The study supports breastfeeding without fortification as post-discharge nutrition in very preterm infants, and it seems superior to preterm formula. View Full-Text
Keywords: post-discharge nutrition; breastfeeding; fortification; preterm infant; cognitive development; Wechsler Intelligence Scale for Children IV; Five to Fifteen Questionnaire post-discharge nutrition; breastfeeding; fortification; preterm infant; cognitive development; Wechsler Intelligence Scale for Children IV; Five to Fifteen Questionnaire
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MDPI and ACS Style

Klamer, A.; Toftlund, L.H.; Grimsson, K.; Halken, S.; Zachariassen, G. IQ Was Not Improved by Post-Discharge Fortification of Breastmilk in Very Preterm Infants. Nutrients 2022, 14, 2709. https://doi.org/10.3390/nu14132709

AMA Style

Klamer A, Toftlund LH, Grimsson K, Halken S, Zachariassen G. IQ Was Not Improved by Post-Discharge Fortification of Breastmilk in Very Preterm Infants. Nutrients. 2022; 14(13):2709. https://doi.org/10.3390/nu14132709

Chicago/Turabian Style

Klamer, Anja, Line H. Toftlund, Kristjan Grimsson, Susanne Halken, and Gitte Zachariassen. 2022. "IQ Was Not Improved by Post-Discharge Fortification of Breastmilk in Very Preterm Infants" Nutrients 14, no. 13: 2709. https://doi.org/10.3390/nu14132709

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