Selenium Status in Paediatric Patients with Neurodevelopmental Diseases
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Trace Element Analysis
2.3. Quantification of Protein Biomarkers of Se and Cu Status
2.4. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. Trace Element Status in Relation to Age and Sex
3.3. Correlations between Serum Cu, Zn, and Se Status and Protein Biomarkers
3.4. Trace Element Status in Relation to Epilepsy
3.5. Trace Element Status in Relation to Phacomatoses
3.6. Trace Element Status in Relation to Mental Development
3.7. Trace Element Status of the Paediatric Patients in Relation to References
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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ICD-10 Code | Disease/Syndrome | Number of Children (%) |
---|---|---|
G40 | Epilepsy | 49 (33.3) |
Q85 | Phacomatoses | 30 (20.4) |
F70–F79 | Intellectual disability | 22 (15.0) |
diverse | Diverse phenotypes | 46 (31.3) |
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Görlich, C.L.; Sun, Q.; Roggenkamp, V.; Hackler, J.; Mehl, S.; Minich, W.B.; Kaindl, A.M.; Schomburg, L. Selenium Status in Paediatric Patients with Neurodevelopmental Diseases. Nutrients 2022, 14, 2375. https://doi.org/10.3390/nu14122375
Görlich CL, Sun Q, Roggenkamp V, Hackler J, Mehl S, Minich WB, Kaindl AM, Schomburg L. Selenium Status in Paediatric Patients with Neurodevelopmental Diseases. Nutrients. 2022; 14(12):2375. https://doi.org/10.3390/nu14122375
Chicago/Turabian StyleGörlich, Christian L., Qian Sun, Viola Roggenkamp, Julian Hackler, Sebastian Mehl, Waldemar B. Minich, Angela M. Kaindl, and Lutz Schomburg. 2022. "Selenium Status in Paediatric Patients with Neurodevelopmental Diseases" Nutrients 14, no. 12: 2375. https://doi.org/10.3390/nu14122375