The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Lipid Absorption Efficiency Contributed to Body Weight Differences Induced by HFD Storage Conditions
3.2. The Enrichment of MCT in HFDfri Is Correlated to the Diet-Induced Body Weight Differences
3.3. HFDfri Led to Exacerbated Liver Damage
3.4. HFDfri Activated UPR-NNMT Signaling in the Liver
3.5. Hepatocyte-Specific Depletion of Nnmt Protected the Liver from MCD Diet-Induced Damages
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Yi, C.; Li, D.; Guo, X.; Wang, J.; Liu, C.; Lu, G.; Sun, Y.; Huang, H.; Hong, S.; Li, J. The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage. Nutrients 2022, 14, 2222. https://doi.org/10.3390/nu14112222
Yi C, Li D, Guo X, Wang J, Liu C, Lu G, Sun Y, Huang H, Hong S, Li J. The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage. Nutrients. 2022; 14(11):2222. https://doi.org/10.3390/nu14112222
Chicago/Turabian StyleYi, Chuanyou, Dandan Li, Xiao Guo, Jinhui Wang, Cenxi Liu, Guangxing Lu, Yan Sun, He Huang, Shangyu Hong, and Jin Li. 2022. "The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage" Nutrients 14, no. 11: 2222. https://doi.org/10.3390/nu14112222