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Nutrients
Volume 14
Issue 1
10.3390/nu14010123
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Article

Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice

by
Qilyu Zhou
1,
Ruyang Yu
1,
Tianlong Liu
1,
Yeye Li
1,
Jia Zhong
2,
Tao Zhang
3,
Zhongjie Liu
1 and
Yusheng Hu
1,*
1
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
2
College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China
3
Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing 102206, China
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(1), 123; https://doi.org/10.3390/nu14010123
Submission received: 9 October 2021 / Revised: 16 December 2021 / Accepted: 24 December 2021 / Published: 28 December 2021
(This article belongs to the Section Nutritional Immunology)
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Abstract

Coix seed is a functional food in the Chinese diet that possesses the ability to alleviate ulcerative colitis clinically. However, the underlying mechanisms remain ambiguous. In this study, we investigated the protective effect of the Coix seed diet on experimental colitis mice. The mice were randomly divided into four groups: control group, model group, Coix seed feed group, and positive control group. The maintenance feed of the mice was replaced with Coix seed feed 10 days before orally administering the mice 5% (w/v) dextran sulfate sodium drink. As a result, the Coix seed feed alleviated colitis symptoms, maintained the complete blood count at a normal level, reduced the pathological score, relieved inflammatory cytokine secretion, and alleviated oxidative stress. Network pharmacology analysis was used for further exploration of the targets of Coix seed feed. The results showed that T-cell regulation is one of the targets of Coix seed feed, and the analysis of the T-lymphocyte subset and innate immune cell distribution of the colon tissue supported the network pharmacology results. In conclusion, Coix seed, as a staple food, can alleviate experimental colitis, and the mechanism may be related to the immune regulation effect of Coix seeds.
Keywords: Coix seed; T-lymphocyte subsets; innate immune cells; dextran sulfate sodium; ulcerative colitis Coix seed; T-lymphocyte subsets; innate immune cells; dextran sulfate sodium; ulcerative colitis
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MDPI and ACS Style

Zhou, Q.; Yu, R.; Liu, T.; Li, Y.; Zhong, J.; Zhang, T.; Liu, Z.; Hu, Y. Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice. Nutrients 2022, 14, 123. https://doi.org/10.3390/nu14010123

AMA Style

Zhou Q, Yu R, Liu T, Li Y, Zhong J, Zhang T, Liu Z, Hu Y. Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice. Nutrients. 2022; 14(1):123. https://doi.org/10.3390/nu14010123

Chicago/Turabian Style

Zhou, Qilyu, Ruyang Yu, Tianlong Liu, Yeye Li, Jia Zhong, Tao Zhang, Zhongjie Liu, and Yusheng Hu. 2022. "Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice" Nutrients 14, no. 1: 123. https://doi.org/10.3390/nu14010123

APA Style

Zhou, Q., Yu, R., Liu, T., Li, Y., Zhong, J., Zhang, T., Liu, Z., & Hu, Y. (2022). Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice. Nutrients, 14(1), 123. https://doi.org/10.3390/nu14010123

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