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Article

Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice

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Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical Centre, Schillingallee 69a, 18057 Rostock, Germany
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Department of Anatomy, Rostock University Medical Centre, Gertrudenstraße 9, 18057 Rostock, Germany
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Department of Systems Biology and Bioinformatics, University of Rostock, Ulmenstraße 69, 18057 Rostock, Germany
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Department of Psychosomatic Medicine and Psychotherapy, Rostock University Medical Centre, Gehlsheimerstraße 20, 18147 Rostock, Germany
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Centre for Transdisciplinary Neurosciences Rostock (CTNR), Rostock University Medical Centre, Gehlsheimerstraße 20, 18147 Rostock, Germany
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Department of Psychiatry, University of Greifswald, Ellernholzstraße 1-2, 17489 Greifswald, Germany
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Institute for Biostatistics and Informatics, Rostock University Medical Centre, Ernst-Heydemann-Straße 8, 18057 Rostock, Germany
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Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Centre, Schillingallee 35, 18057 Rostock, Germany
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Leibniz-Institute for Food Systems Biology, Technical University of Munich, Lise-Meitner-Straße 34, 85354 Freising, Germany
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Author to whom correspondence should be addressed.
Academic Editor: George Dedoussis
Nutrients 2021, 13(9), 2916; https://doi.org/10.3390/nu13092916
Received: 6 July 2021 / Revised: 19 August 2021 / Accepted: 20 August 2021 / Published: 24 August 2021
(This article belongs to the Special Issue Dietary Behaviours and Obesity)
Obesity is one of the most challenging diseases of the 21st century and is accompanied by behavioural disorders. Exercise, dietary adjustments, or time-restricted feeding are the only successful long-term treatments to date. Fibroblast growth factor 21 (FGF21) plays a key role in dietary regulation, but FGF21 resistance is prevalent in obesity. The aim of this study was to investigate in obese mice whether weight reduction leads to improved behaviour and whether these behavioural changes are associated with decreased plasma FGF21 levels. After establishing a model for diet-induced obesity, mice were subjected to three different interventions for weight reduction, namely dietary change, treadmill exercise, or time-restricted feeding. In this study, we demonstrated that only the combination of dietary change and treadmill exercise affected all parameters leading to a reduction in weight, fat, and FGF21, as well as less anxious behaviour, higher overall activity, and improved olfactory detection abilities. To investigate the interrelationship between FGF21 and behavioural parameters, feature selection algorithms were applied designating FGF21 and body weight as one of five highly weighted features. In conclusion, we concluded from the complementary methods that FGF21 can be considered as a potential biomarker for improved behaviour in obese mice after weight reduction. View Full-Text
Keywords: FGF21; treadmill; time restricted feeding; machine learning; behaviour; diet-induced obesity; feature selection; high-fat diet FGF21; treadmill; time restricted feeding; machine learning; behaviour; diet-induced obesity; feature selection; high-fat diet
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MDPI and ACS Style

Power Guerra, N.; Parveen, A.; Bühler, D.; Brauer, D.L.; Müller, L.; Pilz, K.; Witt, M.; Glass, Ä.; Bajorat, R.; Janowitz, D.; Wolkenhauer, O.; Vollmar, B.; Kuhla, A. Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice. Nutrients 2021, 13, 2916. https://doi.org/10.3390/nu13092916

AMA Style

Power Guerra N, Parveen A, Bühler D, Brauer DL, Müller L, Pilz K, Witt M, Glass Ä, Bajorat R, Janowitz D, Wolkenhauer O, Vollmar B, Kuhla A. Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice. Nutrients. 2021; 13(9):2916. https://doi.org/10.3390/nu13092916

Chicago/Turabian Style

Power Guerra, Nicole, Alisha Parveen, Daniel Bühler, David Leon Brauer, Luisa Müller, Kristin Pilz, Martin Witt, Änne Glass, Rika Bajorat, Deborah Janowitz, Olaf Wolkenhauer, Brigitte Vollmar, and Angela Kuhla. 2021. "Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice" Nutrients 13, no. 9: 2916. https://doi.org/10.3390/nu13092916

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