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Article

Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota

1
Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan
2
Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan
3
Kaigen Pharma Co., Ltd., Osaka 541-0045, Japan
4
Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan
5
Transborder Medical Research Center, University of Tsukuba, Ibaraki 305-8575, Japan
6
Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kanagawa 210-0821, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Ana Isabel Alvarez-Mercado and Julio Plaza-Díaz
Nutrients 2021, 13(8), 2812; https://doi.org/10.3390/nu13082812
Received: 31 July 2021 / Revised: 13 August 2021 / Accepted: 13 August 2021 / Published: 16 August 2021
(This article belongs to the Special Issue Dietary Polysaccharides and Gut Microbiota Ecosystem)
Metabolic syndrome (MetS) is a multifactorial chronic metabolic disorder that affects approximately one billion people worldwide. Recent studies have evaluated whether targeting the gut microbiota can prevent MetS. This study aimed to assess the ability of dietary fiber to control MetS by modulating gut microbiota composition. Sodium alginate (SA) is a seaweed-derived dietary fiber that suppresses high-fat diet (HFD)-induced MetS via an effect on the gut microbiota. We observed that SA supplementation significantly decreased body weight gain, cholesterol levels, and fat weight, while improving glucose tolerance in HFD-fed mice. SA changed the gut microbiota composition and significantly increased the abundance of Bacteroides. Antibiotic treatment completely abolished the suppressive effects of SA on MetS. Mechanistically, SA decreased the number of colonic inflammatory monocytes, which promote MetS development, in a gut microbiota-dependent manner. The abundance of Bacteroides was negatively correlated with that of inflammatory monocytes and positively correlated with the levels of several gut metabolites. The present study revealed a novel food function of SA in preventing HFD-induced MetS through its action on gut microbiota. View Full-Text
Keywords: gut microbiota; metabolic syndrome; inflammatory monocytes gut microbiota; metabolic syndrome; inflammatory monocytes
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MDPI and ACS Style

Ejima, R.; Akiyama, M.; Sato, H.; Tomioka, S.; Yakabe, K.; Kimizuka, T.; Seki, N.; Fujimura, Y.; Hirayama, A.; Fukuda, S.; Hase, K.; Kim, Y.-G. Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota. Nutrients 2021, 13, 2812. https://doi.org/10.3390/nu13082812

AMA Style

Ejima R, Akiyama M, Sato H, Tomioka S, Yakabe K, Kimizuka T, Seki N, Fujimura Y, Hirayama A, Fukuda S, Hase K, Kim Y-G. Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota. Nutrients. 2021; 13(8):2812. https://doi.org/10.3390/nu13082812

Chicago/Turabian Style

Ejima, Ryuta, Masahiro Akiyama, Hiroki Sato, Sawako Tomioka, Kyosuke Yakabe, Tatsuki Kimizuka, Natsumi Seki, Yumiko Fujimura, Akiyoshi Hirayama, Shinji Fukuda, Koji Hase, and Yun-Gi Kim. 2021. "Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota" Nutrients 13, no. 8: 2812. https://doi.org/10.3390/nu13082812

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