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A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer

1
Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland
2
Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Sibaji Sarkar
Nutrients 2021, 13(7), 2428; https://doi.org/10.3390/nu13072428
Received: 29 May 2021 / Revised: 9 July 2021 / Accepted: 13 July 2021 / Published: 15 July 2021
(This article belongs to the Special Issue Current Understandings on the Role of Diet and Epigenetics in Cancer)
A still growing interest between human nutrition in relation to health and disease states can be observed. Dietary components shape the composition of microbiota colonizing our gastrointestinal tract which play a vital role in maintaining human health. There is a strong evidence that diet, gut microbiota and their metabolites significantly influence our epigenome, particularly through the modulation of microRNAs. These group of small non-coding RNAs maintain cellular homeostasis, however any changes leading to impaired expression of miRNAs contribute to the development of different pathologies, including neoplastic diseases. Imbalance of intestinal microbiota due to diet is primary associated with the development of colorectal cancer as well as other types of cancers. In the present work we summarize current knowledge with particular emphasis on diet-microbiota-miRNAs axis and its relation to the development of colorectal cancer. View Full-Text
Keywords: nutrition; diet; gut microbiota; gut microbiota-derived metabolites; miRNAs; epigenetic; colorectal cancer nutrition; diet; gut microbiota; gut microbiota-derived metabolites; miRNAs; epigenetic; colorectal cancer
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MDPI and ACS Style

Guz, M.; Jeleniewicz, W.; Malm, A.; Korona-Glowniak, I. A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer. Nutrients 2021, 13, 2428. https://doi.org/10.3390/nu13072428

AMA Style

Guz M, Jeleniewicz W, Malm A, Korona-Glowniak I. A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer. Nutrients. 2021; 13(7):2428. https://doi.org/10.3390/nu13072428

Chicago/Turabian Style

Guz, Małgorzata, Witold Jeleniewicz, Anna Malm, and Izabela Korona-Glowniak. 2021. "A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer" Nutrients 13, no. 7: 2428. https://doi.org/10.3390/nu13072428

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