The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
Abstract
:1. Introduction
2. MiRNAs and Nutrition
3. The Role(s) of MiR-155 in Intra- and Intercellular Signaling
4. The Role of MiR-155 in Regulation of the Immune Response
5. The Role of MiR-155 in Metabolism
6. The Role of MiR-155 in Inflammation
7. The Role of MiR-155 in Response to Various Dietary Nutrients
8. MiR-155 in Carcinogenesis and MiRNA-Based Monitoring of Disease Progression
9. Conclusions and Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Dietary Compound | Study Type | Dose | MiR-155 Expression Level | MiR-155 Targets | Biological Effects | Reference |
---|---|---|---|---|---|---|
Allyl-isothiocyanate | In vitro: RAW264.7 macrophages | 1–10 μM | ↓ | ↓Nrf2, HO, p65 | ↓Inflammation | [81] |
In vivo: C57BL/6 mice | 15 mg/kg | ↓ | ↓Nrf2, HO, p65 | ↓Inflammation | [81] | |
Quercetin | In vitro: RAW264.7 cells | 25–100 μM | ↓ | ↓TNF-α | ↓Inflammation | [121] |
Resveratrol | Clinical study | 8 mg/day | ↓ | ↓TNF-α | ↓Inflammation | [123] |
Curcumin | In vitro/BV2 microglial cells | 50 μM | ↓ | ↓PI3K, p85a, and AKT | ↓Inflammation | [126] |
Apigenin | In vivo/Male C57BL/6J mice | 50 mg/kg | ↓ | ↓TNF-α | ↓Inflammation | [115] |
Pomegranate polyphenolics | In vivo/Female athymic BALB/c nude mice | 0.8 mg gallic acid equivalent (GAE)/kg/day | ↓ | ↓NF-kB | ↓Inflammation | [128] |
Vitamin C | Clinical | 1250 mg/day | ↓ | ↓ROS | ↓Inflammation ↑Antioxidant activity | [45] |
In vitro/MT-2 cells | 100 µg/mL | ↓ | ↑IFN-γ | ↑Antiproliferative and immunomodulatory anti-HTLV-1 effects | [125] | |
In vivo | 20 µg/mL | ↓ | ↑TGF-β1 and SMAD 1,2 | ↑Wound healing rate | [127] | |
1,25-dihydroxy-vitamin D | In vivo/mice | 20 nM | ↓ | ↓NF-κB | ↓Inflammation, innate immunity | [131] |
In vivo/C57BL/6J mice | 3000 IU/kg of body weight | ↓ | ↓NF-κB | ↓Inflammation | [130] | |
In vitro/MDM cells | 0.1 nM | ↓ | ↑SOCS-1 | ↓Inflammation | [24] | |
PUFAs | In vitro/RAW264.7 cells | 15 µmol/L | ↓ | ↓TLR | ↓Inflammation | [133] |
Oleic acid | In vitro/THP-1 cells | 100 μM | ↓ | ↓TLR4 | ↓ Inflammation | [135] |
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Zanoaga, O.; Braicu, C.; Chiroi, P.; Andreea, N.; Hajjar, N.A.; Mărgărit, S.; Korban, S.S.; Berindan-Neagoe, I. The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation. Nutrients 2021, 13, 2245. https://doi.org/10.3390/nu13072245
Zanoaga O, Braicu C, Chiroi P, Andreea N, Hajjar NA, Mărgărit S, Korban SS, Berindan-Neagoe I. The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation. Nutrients. 2021; 13(7):2245. https://doi.org/10.3390/nu13072245
Chicago/Turabian StyleZanoaga, Oana, Cornelia Braicu, Paul Chiroi, Nutu Andreea, Nadim Al Hajjar, Simona Mărgărit, Schuyler S. Korban, and Ioana Berindan-Neagoe. 2021. "The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation" Nutrients 13, no. 7: 2245. https://doi.org/10.3390/nu13072245