Next Article in Journal
Cardiovascular Risk and Endothelial Dysfunction in Primary Sjogren Syndrome Is Related to the Disease Activity
Previous Article in Journal
Association of Heavy Metals with Overall Mortality in a Taiwanese Population
Article

Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case–Control Study

1
Clinical Nutrition, Hospital Universitario “Dr. José Eleuterio González” and Medicine Faculty, Autonomous University of Nuevo León, Monterrey 64460, Mexico
2
International Iberoamerican University of México, Campeche 24560, Mexico
3
Genetics Department, Hospital Universitario “Dr. José Eleuterio González” and Medicine Faculty, Autonomous University of Nuevo León, Monterrey 64460, Mexico
4
Gynecology and Obstetrics Department, Hospital Universitario “Dr. José Eleuterio González” and Medicine Faculty, Autonomous University of Nuevo León, Monterrey 64460, Mexico
5
Medicine Faculty, Autonomous University of Baja California, Mexicali 21000, Mexico
6
Medicine Faculty, National University of Colombia, Bogotá 111321, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Dina Bellizzi
Nutrients 2021, 13(6), 2071; https://doi.org/10.3390/nu13062071
Received: 14 May 2021 / Revised: 4 June 2021 / Accepted: 7 June 2021 / Published: 17 June 2021
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
Background: DNA methylation is the best epigenetic mechanism for explaining the interactions between nutrients and genes involved in intrauterine growth and development programming. A possible contributor of methylation abnormalities to congenital heart disease is the folate methylation regulatory pathway; however, the mechanisms and methylation patterns of VSD-associated genes are not fully understood. Objective: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20). Methods: Prospective case–control study; 48 mothers and their children were evaluated. The mothers’ dietary variables were collected through a food frequency questionnaire focusing on FA and the consumption of supplements with FA. The MS of promoters of genes was determined in the children. Results: The intake of FA supplements was significantly higher in the control mothers. In terms of maternal folic acid consumption, significant differences were found in the first trimester of pregnancy. Significant differences were observed in the MS of MTHFR and AXIN1 genes in VSD and control children. A correlation between maternal FA supplementation and MS of AXIN1 and TBX20 genes was found in control and VSD children, respectively. Conclusions: A lower MS of AXIN1 genes and a higher MS of TBX20 genes is associated with FA maternal supplementation. View Full-Text
Keywords: folic acid intake; ventricular septal defects; congenital heart disease; methylation status; AXIN1; MTHFR; TBX1; TBX20 folic acid intake; ventricular septal defects; congenital heart disease; methylation status; AXIN1; MTHFR; TBX1; TBX20
MDPI and ACS Style

González-Peña, S.M.; Calvo-Anguiano, G.; Martínez-de-Villarreal, L.E.; Ancer-Rodríguez, P.R.; Lugo-Trampe, J.J.; Saldivar-Rodríguez, D.; Hernández-Almaguer, M.D.; Calzada-Dávila, M.; Guerrero-Orjuela, L.S.; Campos-Acevedo, L.D. Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case–Control Study. Nutrients 2021, 13, 2071. https://doi.org/10.3390/nu13062071

AMA Style

González-Peña SM, Calvo-Anguiano G, Martínez-de-Villarreal LE, Ancer-Rodríguez PR, Lugo-Trampe JJ, Saldivar-Rodríguez D, Hernández-Almaguer MD, Calzada-Dávila M, Guerrero-Orjuela LS, Campos-Acevedo LD. Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case–Control Study. Nutrients. 2021; 13(6):2071. https://doi.org/10.3390/nu13062071

Chicago/Turabian Style

González-Peña, Sandra M., Geovana Calvo-Anguiano, Laura E. Martínez-de-Villarreal, Patricia R. Ancer-Rodríguez, José J. Lugo-Trampe, Donato Saldivar-Rodríguez, María D. Hernández-Almaguer, Melissa Calzada-Dávila, Ligia S. Guerrero-Orjuela, and Luis D. Campos-Acevedo 2021. "Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case–Control Study" Nutrients 13, no. 6: 2071. https://doi.org/10.3390/nu13062071

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop