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Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study

1
Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux, Bordeaux Population Health, F-33000 Bordeaux, France
2
Service d’Ophtalmologie, Centre Hospitalier Universitaire de Bordeaux, 33000 Bordeaux, France
3
DSM Nutritional Products, 4303 Kaiserraugst, Switzerland
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(6), 2047; https://doi.org/10.3390/nu13062047
Received: 10 May 2021 / Revised: 1 June 2021 / Accepted: 8 June 2021 / Published: 15 June 2021
(This article belongs to the Section Nutritional Epidemiology)
Lutein and zeaxanthin may lower the risk of age-related macular degeneration (AMD). We evaluated the associations of plasma lutein and zeaxanthin with the incidence of advanced AMD in the Alienor study (Antioxydants Lipides Essentiels Nutrition et Maladies Oculaires). Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). The present study included 609 participants with complete ophthalmologic and plasma carotenoids data. Examinations were performed every two years over an eight-year period (2006 to 2017). Plasma lutein and zeaxanthin were determined at baseline from fasting blood samples using high-performance liquid chromatography. Cox proportional hazard models were used to assess associations between plasma lutein, zeaxanthin, and their (total cholesterol (TC) + triglycerides (TG)) ratios with AMD. Among the 609 included participants, 54 developed advanced incident AMD during a median follow-up time of 7.6 years (range 0.7 to 10.4). Participants with higher plasma lutein had a reduced risk for incident advanced AMD in the fully adjusted model (HR = 0.63 per 1-SD increase (95% CI, 0.41–0.97), p = 0.03). A similar association was observed using the lutein/(TC + TG) ratio (HR = 0.59 (95% CI, 0.39–0.90), p = 0.01). No associations were evidenced for other carotenoids. Higher plasma lutein was associated with a 37% reduced risk of incident advanced AMD. View Full-Text
Keywords: age-related macular degeneration; lutein; biomarker; epidemiology; nutrition; cohort; risk; population age-related macular degeneration; lutein; biomarker; epidemiology; nutrition; cohort; risk; population
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MDPI and ACS Style

Merle, B.M.J.; Cougnard-Grégoire, A.; Korobelnik, J.-F.; Schalch, W.; Etheve, S.; Rougier, M.-B.; Féart, C.; Samieri, C.; Delyfer, M.-N.; Delcourt, C. Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study. Nutrients 2021, 13, 2047. https://doi.org/10.3390/nu13062047

AMA Style

Merle BMJ, Cougnard-Grégoire A, Korobelnik J-F, Schalch W, Etheve S, Rougier M-B, Féart C, Samieri C, Delyfer M-N, Delcourt C. Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study. Nutrients. 2021; 13(6):2047. https://doi.org/10.3390/nu13062047

Chicago/Turabian Style

Merle, Bénédicte M.J., Audrey Cougnard-Grégoire, Jean-François Korobelnik, Wolfgang Schalch, Stéphane Etheve, Marie-Bénédicte Rougier, Catherine Féart, Cécilia Samieri, Marie-Noëlle Delyfer, and Cécile Delcourt. 2021. "Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study" Nutrients 13, no. 6: 2047. https://doi.org/10.3390/nu13062047

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