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The Impact of the First 2020 COVID-19 Lockdown on the Metabolic Control of Patients with Phenylketonuria

Department of Organization and Management in Health Care, Poznan University of Medical Sciences, Przybyszewskiego 39, 60-356 Poznań, Poland
Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Białystok, Poland
Research and Development Center, Regional Specialist Hospital, 51-124 Wrocław, Poland
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 60-572 Poznań, Poland
University Children’s Hospital, Jagiellonian University, 30-663 Krakow, Poland
Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 80-210 Gdansk, Poland
Voivodship Children Hospital, 85-667 Bydgoszcz, Poland
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Liakopoulos
Nutrients 2021, 13(6), 2024;
Received: 30 April 2021 / Revised: 30 May 2021 / Accepted: 10 June 2021 / Published: 12 June 2021
(This article belongs to the Special Issue Dietary Modifications from Benefits to Pathology)
The present study assessed patients’ metabolic control of phenylketonuria (PKU) during the first 2020 COVID-19 lockdown in Poland. Blood (phenylalanine) Phe results of the tests of 535 patients, performed in 2019 and in the first months of 2020, were analysed. The six-week lockdown period was compared to the preceding six-week period as well as to the two corresponding periods of 2019 (three non-lockdown periods). More patients failed to perform Phe tests in the lockdown period (32.7%) than in non-lockdown periods (15.6%, 15.1%, 17.2%; p < 0.001 for all). The median Phe levels for those patients who performed testing in all the four periods did not differ between periods. However, these patients tended to perform only one test during the lockdown (ORs: 1.43 to 1.60; 95% CI: from 1.01–2.04 to 1.11–2.30, p-value 0.02 to 0.005). Patients who did not take blood during the lockdown (46.7%) performed significantly fewer blood tests in the remaining periods (median <IQR>: 1 <0–1> vs. 2 <1–4>; p < 0.001). In conclusion, direct assessment of patients’ compliance based upon Phe levels during the pandemic lockdown was not possible. Pre-pandemic non-compliant patients frequently failed to perform the test during the lockdown, whereas the previously compliant ones were more likely to perform only one test. This strongly suggests that metabolic control might have worsened. View Full-Text
Keywords: phenylketonuria; PKU; COVID-19 pandemic; compliance phenylketonuria; PKU; COVID-19 pandemic; compliance
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MDPI and ACS Style

Walkowiak, D.; Mikołuć, B.; Mozrzymas, R.; Kałużny, Ł.; Didycz, B.; Jaglowska, J.; Kurylak, D.; Walkowiak, J. The Impact of the First 2020 COVID-19 Lockdown on the Metabolic Control of Patients with Phenylketonuria. Nutrients 2021, 13, 2024.

AMA Style

Walkowiak D, Mikołuć B, Mozrzymas R, Kałużny Ł, Didycz B, Jaglowska J, Kurylak D, Walkowiak J. The Impact of the First 2020 COVID-19 Lockdown on the Metabolic Control of Patients with Phenylketonuria. Nutrients. 2021; 13(6):2024.

Chicago/Turabian Style

Walkowiak, Dariusz, Bożena Mikołuć, Renata Mozrzymas, Łukasz Kałużny, Bożena Didycz, Joanna Jaglowska, Danuta Kurylak, and Jarosław Walkowiak. 2021. "The Impact of the First 2020 COVID-19 Lockdown on the Metabolic Control of Patients with Phenylketonuria" Nutrients 13, no. 6: 2024.

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