Next Article in Journal
Do Lifestyle Interventions in Pregnant Women with Overweight or Obesity Have an Effect on Neonatal Adiposity? A Systematic Review with Meta-Analysis
Previous Article in Journal
“Aggressive” Feeding of Very Preterm Neonates and Body Mass Index at School Age
Article

The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study

1
Inserm UMR 1073, 76000 Rouen, France
2
Nutrition Department, University Hospital, 76000 Rouen, France
3
Department of Biology, Rouen Normandy University, 76130 Mont-Saint-Aignan, France
4
TargEDys SA, 91160 Longjumeau, France
5
Practice for General Medicine, 12169 Berlin, Germany
6
Analyze & Realize GmbH, 13467 Berlin, Germany
7
Inserm UMR 1239, 76130 Mont-Saint-Aignan, France
*
Author to whom correspondence should be addressed.
Academic Editor: Margarita Aguilera
Nutrients 2021, 13(6), 1902; https://doi.org/10.3390/nu13061902
Received: 23 April 2021 / Revised: 27 May 2021 / Accepted: 30 May 2021 / Published: 1 June 2021
(This article belongs to the Section Prebiotics and Probiotics)
Background: Increasing evidence supports the role of the gut microbiota in the control of body weight and feeding behavior. Moreover, recent studies have reported that the probiotic strain Hafnia alvei HA4597® (HA), which produces the satietogenic peptide ClpB mimicking the effect of alpha-MSH, reduced weight gain and adiposity in rodent models of obesity. Methods: To investigate the clinical efficacy of HA, 236 overweight subjects were included, after written informed consent, in a 12-week prospective, double-blind, randomized study. All subjects received standardized counselling for a −20% hypocaloric diet and were asked to maintain their usual physical activity. Subjects of the HA group received two capsules per day providing 100 billion bacteria per day and subjects in the Placebo (P) group received two placebo capsules. The primary endpoint was the percentage of subjects achieving a weight loss of at least 3% after 12 weeks. Intention-to-treat statistical analysis was performed using exact-Fischer, Mann-Whitney and paired-Wilcoxon tests as appropriate. Results: In the HA group, significantly more subjects (+33%) met the primary endpoint than in the P group (54.9 vs. 41.4%, p = 0.048). In the HA group, an increased feeling of fullness (p = 0.009) and a greater loss of hip circumference (p < 0.001) at 12 weeks were also observed. Fasting glycemia at 12 weeks was significantly lower (p < 0.05) in the HA compared to P group. Clinical and biological tolerance was good in both groups. Conclusions: A 12-week treatment with the probiotic strain H. alvei HA4597® significantly improves weight loss, feeling of fullness and reduction of hip circumference in overweight subjects following moderate hypocaloric diet. These data support the use of H. alvei HA4597® in the global management of excess weight. View Full-Text
Keywords: overweight subjects; gut microbiota; probiotics; H. alvei HA4597; HA4597®; feeling of fullness; appetite; hip circumference overweight subjects; gut microbiota; probiotics; H. alvei HA4597; HA4597®; feeling of fullness; appetite; hip circumference
Show Figures

Figure 1

MDPI and ACS Style

Déchelotte, P.; Breton, J.; Trotin-Picolo, C.; Grube, B.; Erlenbeck, C.; Bothe, G.; Fetissov, S.O.; Lambert, G. The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study. Nutrients 2021, 13, 1902. https://doi.org/10.3390/nu13061902

AMA Style

Déchelotte P, Breton J, Trotin-Picolo C, Grube B, Erlenbeck C, Bothe G, Fetissov SO, Lambert G. The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2021; 13(6):1902. https://doi.org/10.3390/nu13061902

Chicago/Turabian Style

Déchelotte, Pierre, Jonathan Breton, Clémentine Trotin-Picolo, Barbara Grube, Constantin Erlenbeck, Gordana Bothe, Sergueï O. Fetissov, and Grégory Lambert. 2021. "The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study" Nutrients 13, no. 6: 1902. https://doi.org/10.3390/nu13061902

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop