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Nutrients
Volume 13
Issue 6
10.3390/nu13061886
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Review

Effects of Soy Isoflavones on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

by
Agnieszka Barańska
1,*,
Agata Błaszczuk
2,
Małgorzata Polz-Dacewicz
2,
Wiesław Kanadys
3,
Maria Malm
1,
Mariola Janiszewska
1 and
Marian Jędrych
1
1
Department of Medical Informatics and Statistics with E-Learning Lab, Medical University of Lublin, 20-090 Lublin, Poland
2
Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland
3
Specialistic Medical Center Czechow, 20-848 Lublin, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(6), 1886; https://doi.org/10.3390/nu13061886
Submission received: 6 April 2021 / Revised: 25 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Nutrition and Lipid Metabolism in Type 2 Diabetes)
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Abstract

The aim of the report was to investigate the impact of soy protein and isoflavones on glucose homeostasis and lipid profile in type 2 diabetes. The studies used in this report were identified by searching through the MEDLINE and EMBASE databases (up to 2020). Meta-regression and subgroup analyses were performed to explore the influence of covariates on net glycemic control and lipid changes. Weighted mean differences and 95% confidence intervals (CI) were calculated by using random-effect models. Changes in the lipid profile showed statistically significant decreases in total cholesterol and LDL-C concentrations: ‒0.21 mmol/L; 95% CI, ‒0.33 to ‒0.09; p = 0.0008 and ‒0.20 mmol/L; 95% CI, ‒0.28 to ‒0.12; p < 0.0001, respectively, as well as in HDL-C (−0.02 mmol/L; 95% CI, −0.05 to 0.01; p = 0.2008 and triacylglycerols (−0.19 mmol/L; 95% CI, −0.48 to 0.09; p = 0.1884). At the same time, a meta-analysis of the included studies revealed statistically insignificant reduction in fasting glucose, insulin, HbA1c, and HOMA-IR (changes in glucose metabolism) after consumption of soy isoflavones. The observed ability of both extracted isoflavone and soy protein with isoflavones to modulate the lipid profile suggests benefits in preventing cardiovascular events in diabetic subjects. Further multicenter studies based on larger and longer duration studies are necessary to determine their beneficial effect on glucose and lipid metabolism.
Keywords: T2DM; soy isoflavones; lipid profile; total cholesterol; HDL-C; LDL-C; triacylglycerol; glycemic control; HbA1c; HOMA-IR T2DM; soy isoflavones; lipid profile; total cholesterol; HDL-C; LDL-C; triacylglycerol; glycemic control; HbA1c; HOMA-IR

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MDPI and ACS Style

Barańska, A.; Błaszczuk, A.; Polz-Dacewicz, M.; Kanadys, W.; Malm, M.; Janiszewska, M.; Jędrych, M. Effects of Soy Isoflavones on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2021, 13, 1886. https://doi.org/10.3390/nu13061886

AMA Style

Barańska A, Błaszczuk A, Polz-Dacewicz M, Kanadys W, Malm M, Janiszewska M, Jędrych M. Effects of Soy Isoflavones on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021; 13(6):1886. https://doi.org/10.3390/nu13061886

Chicago/Turabian Style

Barańska, Agnieszka, Agata Błaszczuk, Małgorzata Polz-Dacewicz, Wiesław Kanadys, Maria Malm, Mariola Janiszewska, and Marian Jędrych. 2021. "Effects of Soy Isoflavones on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" Nutrients 13, no. 6: 1886. https://doi.org/10.3390/nu13061886

APA Style

Barańska, A., Błaszczuk, A., Polz-Dacewicz, M., Kanadys, W., Malm, M., Janiszewska, M., & Jędrych, M. (2021). Effects of Soy Isoflavones on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 13(6), 1886. https://doi.org/10.3390/nu13061886

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