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Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

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Institute of Sports Sciences, University of Taipei, 101 Zhongcheng Rd. Section 2, Shilin District, Taipei 111, Taiwan
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Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
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Faculty of Medicine and Institute of Emergency and Critical Medicine, National Yang Ming Chiao Tung University College Medicine, Taipei 112, Taiwan
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Department of Exercise and Sport Science, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA
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Graduate Institute of Sports Training, University of Taipei, 101 Zhongcheng Rd. Section 2, Shilin District, Taipei 111, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(6), 1880; https://doi.org/10.3390/nu13061880
Received: 31 March 2021 / Revised: 20 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021
(This article belongs to the Section Sports Nutrition)
Previous studies have reported the positive effects of branched-chain amino acids (BCAAs) supplementation on lowering plasma markers of muscle damage and subjective soreness after resistance exercise. However, a variety of factors can potentially moderate its efficacy. This meta-analysis aimed to summarize the evidence regarding the effect of BCAAs supplementation on plasma muscle damage markers and soreness after resistance exercise in only trained males, by considering the plasma lactate dehydrogenase (LDH) and creatine kinase (CK). Randomized controlled trials were identified through a computerized literature search for the period 2010–2020. The pooled data were analyzed with the random-effects model and heterogeneity using I2. Cochrane Collaboration tools was used for the assessment of risk of bias. Nine studies met the inclusion criteria. A positive effect was found for CK at <24, 24, and 48 h after exercise and for muscle soreness at <24 h only. However, the positive effect was not evident for plasma LDH at any follow-up time. Different outcomes for post-exercise responses may suggest that BCAAs supplementation can attenuate muscle damage and ameliorate muscle soreness after resistance exercise in trained males. View Full-Text
Keywords: branched-chain amino acids; muscle damage; muscle soreness; creatine kinase; lactate dehydrogenase; resistance exercise; inflammatory response; meta-analysis branched-chain amino acids; muscle damage; muscle soreness; creatine kinase; lactate dehydrogenase; resistance exercise; inflammatory response; meta-analysis
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MDPI and ACS Style

Khemtong, C.; Kuo, C.-H.; Chen, C.-Y.; Jaime, S.J.; Condello, G. Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials. Nutrients 2021, 13, 1880. https://doi.org/10.3390/nu13061880

AMA Style

Khemtong C, Kuo C-H, Chen C-Y, Jaime SJ, Condello G. Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021; 13(6):1880. https://doi.org/10.3390/nu13061880

Chicago/Turabian Style

Khemtong, Chutimon, Chia-Hua Kuo, Chih-Yen Chen, Salvador J. Jaime, and Giancarlo Condello. 2021. "Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials" Nutrients 13, no. 6: 1880. https://doi.org/10.3390/nu13061880

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