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Article

Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice

1
Japan Society for the Promotion of Science, Kojimachi Business Center Building, Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
2
Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Japan
3
Department of Food Science and Nutrition, Doshisha Women’s College of Liberal Arts, Tera-machi Nishiiru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-0893, Japan
4
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
5
Department of Clinical Laboratory, Faculty of Health Sciences, Tsukuba International University, 6-20-1 Manabe, Tsuchiura, Ibaraki 300-0051, Japan
6
Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Laurent A. Messonnier
Nutrients 2021, 13(5), 1735; https://doi.org/10.3390/nu13051735
Received: 19 April 2021 / Revised: 11 May 2021 / Accepted: 18 May 2021 / Published: 20 May 2021
The effects of exercise on nutrient digestion and absorption in the intestinal tract are not well understood. A few studies have reported that exercise training increases the expression of molecules involved in carbohydrate digestion and absorption. Exercise was also shown to increase the blood concentration of glucagon-like peptide-2 (GLP-2), which regulates carbohydrate digestion and absorption in the small intestine. Therefore, we investigated the effects of exercise on the expression of molecules involved in intestinal digestion and absorption, including GLP-2. Six-week-old male mice were divided into a sedentary (SED) and low-intensity exercise (LEx) group. LEx mice were required to run on a treadmill (12.5 m/min, 1 h), whereas SED mice rested. All mice were euthanized 1 h after exercise or rest, and plasma, jejunum, ileum, and colon samples were collected, followed by analysis via IHC, EIA, and immunoblotting. The levels of plasma GLP-2 and the jejunum expression of the GLP-2 receptor, sucrase-isomaltase (SI), and glucose transporter 2 (GLUT2) were higher in LEx mice. Thus, we showed that acute low-intensity exercise affects the expression of molecules involved in intestinal carbohydrate digestion and absorption via GLP-2. Our results suggest that exercise might be beneficial for small intestine function in individuals with intestinal frailty. View Full-Text
Keywords: low-intensity exercise; intestine; sodium-dependent glucose transporter; glucose transporter 2; glucagon-like peptide 2 low-intensity exercise; intestine; sodium-dependent glucose transporter; glucose transporter 2; glucagon-like peptide 2
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MDPI and ACS Style

Aoki, K.; Suzuki, T.; Hui, F.; Nakano, T.; Yanazawa, K.; Yonamine, M.; Fujita, S.; Sugasawa, T.; Yoshida, Y.; Omi, N.; Kawakami, Y.; Takekoshi, K. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice. Nutrients 2021, 13, 1735. https://doi.org/10.3390/nu13051735

AMA Style

Aoki K, Suzuki T, Hui F, Nakano T, Yanazawa K, Yonamine M, Fujita S, Sugasawa T, Yoshida Y, Omi N, Kawakami Y, Takekoshi K. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice. Nutrients. 2021; 13(5):1735. https://doi.org/10.3390/nu13051735

Chicago/Turabian Style

Aoki, Kai, Takuji Suzuki, Fang Hui, Takuro Nakano, Koki Yanazawa, Masato Yonamine, Shinichiro Fujita, Takehito Sugasawa, Yasuko Yoshida, Naomi Omi, Yasushi Kawakami, and Kazuhiro Takekoshi. 2021. "Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice" Nutrients 13, no. 5: 1735. https://doi.org/10.3390/nu13051735

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