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Article

Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults

Nutrition Science, Purdue University, West Lafayette, IN 47907, USA
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Author to whom correspondence should be addressed.
Academic Editor: Susan J. Whiting
Nutrients 2021, 13(5), 1610; https://doi.org/10.3390/nu13051610
Received: 23 March 2021 / Revised: 7 May 2021 / Accepted: 8 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Implications of Mineral-Mineral Interactions for Human Health)
Increased potassium intake has been linked to improvements in cardiovascular and other health outcomes. We assessed increasing potassium intake through food or supplements as part of a controlled diet on blood pressure (BP), microcirculation (endothelial function), and potassium and sodium retention in thirty pre-hypertensive-to-hypertensive men and women. Participants were randomly assigned to a sequence of four 17 day dietary potassium treatments: a basal diet (control) of 60 mmol/d and three phases of 85 mmol/d added as potatoes, French fries, or a potassium gluconate supplement. Blood pressure was measured by manual auscultation, cutaneous microvascular and endothelial function by thermal hyperemia, utilizing laser Doppler flowmetry, and mineral retention by metabolic balance. There were no significant differences among treatments for end-of-treatment BP, change in BP over time, or endothelial function using a mixed-model ANOVA. However, there was a greater change in systolic blood pressure (SBP) over time by feeding baked/boiled potatoes compared with control (−6.0 mmHg vs. −2.6 mmHg; p = 0.011) using contrast analysis. Potassium retention was highest with supplements. Individuals with a higher cardiometabolic risk may benefit by increasing potassium intake. This trial was registered at ClinicalTrials.gov as NCT02697708. View Full-Text
Keywords: potassium; sodium; blood pressure; controlled feeding study; microcirculation; retention; cardiometabolic risk potassium; sodium; blood pressure; controlled feeding study; microcirculation; retention; cardiometabolic risk
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MDPI and ACS Style

Stone, M.S.; Martin, B.R.; Weaver, C.M. Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults. Nutrients 2021, 13, 1610. https://doi.org/10.3390/nu13051610

AMA Style

Stone MS, Martin BR, Weaver CM. Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults. Nutrients. 2021; 13(5):1610. https://doi.org/10.3390/nu13051610

Chicago/Turabian Style

Stone, Michael S., Berdine R. Martin, and Connie M. Weaver. 2021. "Short-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive Adults" Nutrients 13, no. 5: 1610. https://doi.org/10.3390/nu13051610

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