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Systematic Review

A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder

Department of Psychology, University of Rome ‘La Sapienza’, 00185 Rome, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Fernando Fernandez-Aranda
Nutrients 2021, 13(3), 848; https://doi.org/10.3390/nu13030848
Received: 3 February 2021 / Revised: 24 February 2021 / Accepted: 1 March 2021 / Published: 5 March 2021
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
The genetic polymorphisms involved in the physiopathology of binge eating disorder (BED) are currently unclear. This systematic review aims to highlight and summarize the research on polymorphisms that is conducted in the BED. We looked for observational studies where there was a genetic comparison between adults with BED, in some cases also with obesity or overweight, and healthy controls or obesity/overweight without BED. Our protocol was written using PRISMA. It is registered at PROSPERO (identification: CRD42020198645). To identify potentially relevant documents, the following bibliographic databases were searched without a time limit, but until September 2020: PubMed, PsycINFO, Scopus, and Web of Science. In total, 21 articles were included in the qualitative analysis of the systematic review, as they met the eligibility criteria. Within the selected studies, 41 polymorphisms of 17 genes were assessed. Overall, this systematic review provides a list of potentially useful genetic polymorphisms involved in BED: 5-HTTLPR (5-HTT), Taq1A (ANKK1/DRD2), A118G (OPRM1), C957T (DRD2), rs2283265 (DRD2), Val158Met (COMT), rs6198 (GR), Val103Ile (MC4R), Ile251Leu (MC4R), rs6265 (BNDF), and Leu72Met (GHRL). It is important to emphasize that Taq1A is the polymorphism that showed, in two different research groups, the most significant association with BED. The remaining polymorphisms need further evidence to be confirmed. View Full-Text
Keywords: genetics; binge eating disorder; systematic review; obesity; polymorphisms; dopamine; serotonin genetics; binge eating disorder; systematic review; obesity; polymorphisms; dopamine; serotonin
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MDPI and ACS Style

Manfredi, L.; Accoto, A.; Couyoumdjian, A.; Conversi, D. A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder. Nutrients 2021, 13, 848. https://doi.org/10.3390/nu13030848

AMA Style

Manfredi L, Accoto A, Couyoumdjian A, Conversi D. A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder. Nutrients. 2021; 13(3):848. https://doi.org/10.3390/nu13030848

Chicago/Turabian Style

Manfredi, Lucia; Accoto, Alessandra; Couyoumdjian, Alessandro; Conversi, David. 2021. "A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder" Nutrients 13, no. 3: 848. https://doi.org/10.3390/nu13030848

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