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Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
Article

Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study

1
Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita 565-0871, Japan
2
Department of Food and Life Science, School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan
3
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
*
Author to whom correspondence should be addressed.
Membership of the JPHC Study Group is provided in the Acknowledgments.
Academic Editor: Lynnette Ferguson
Nutrients 2021, 13(3), 780; https://doi.org/10.3390/nu13030780
Received: 13 January 2021 / Revised: 13 February 2021 / Accepted: 23 February 2021 / Published: 27 February 2021
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
Acrylamide can be carcinogenic to humans. However, the association between the acrylamide and the risks of renal cell, prostate, and bladder cancers in Asians has not been assessed. We aimed to investigate this association in the Japan Public Health Center-based Prospective Study data in 88,818 Japanese people (41,534 men and 47,284 women) who completed a food frequency questionnaire in the five-year follow-up survey in 1995 and 1998. A validated food frequency questionnaire was used to assess the dietary acrylamide intake. Cox proportional hazard regression models were used to estimate hazard ratios and 95% confidence intervals (CIs). During a mean follow-up of 15.5 years (15.2 years of prostate cancer), 208 renal cell cancers, 1195 prostate cancers, and 392 bladder cancers were diagnosed. Compared to the lowest quintile of acrylamide intake, the multivariate hazard ratios for the highest quintile were 0.71 (95% CI: 0.38–1.34, p for trend = 0.294), 0.96 (95% CI: 0.75–1.22, p for trend = 0.726), and 0.87 (95% CI: 0.59–1.29, p for trend = 0.491) for renal cell, prostate, and bladder cancers, respectively, in the multivariate-adjusted model. No significant associations were observed in the stratified analyses based on smoking. Dietary acrylamide intake was not associated with the risk of renal cell, prostate, and bladder cancers. View Full-Text
Keywords: acrylamide; renal cell; prostate and bladder cancer; diet; cohort acrylamide; renal cell; prostate and bladder cancer; diet; cohort
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MDPI and ACS Style

Ikeda, S.; Sobue, T.; Kitamura, T.; Ishihara, J.; Kotemori, A.; Zha, L.; Liu, R.; Sawada, N.; Iwasaki, M.; Tsugane, S.; on behalf of the JPHC Study Group. Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study. Nutrients 2021, 13, 780. https://doi.org/10.3390/nu13030780

AMA Style

Ikeda S, Sobue T, Kitamura T, Ishihara J, Kotemori A, Zha L, Liu R, Sawada N, Iwasaki M, Tsugane S, on behalf of the JPHC Study Group. Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study. Nutrients. 2021; 13(3):780. https://doi.org/10.3390/nu13030780

Chicago/Turabian Style

Ikeda, Sayaka, Tomotaka Sobue, Tetsuhisa Kitamura, Junko Ishihara, Ayaka Kotemori, Ling Zha, Rong Liu, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, and on behalf of the JPHC Study Group. 2021. "Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study" Nutrients 13, no. 3: 780. https://doi.org/10.3390/nu13030780

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