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Article

Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study

1
Virta Health, San Francisco, CA 94105, USA
2
University of Washington School of Medicine Wyoming WWAMI, Laramie, WY 82071, USA
3
Department of Bariatric and Medical Weight Loss, Indiana University Health-Arnett, Lafayette, IN 47905, USA
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Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA
5
Abbott Diabetes Care, Inc., Alameda, CA 94502, USA
6
Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Antonio Brunetti
Nutrients 2021, 13(3), 749; https://doi.org/10.3390/nu13030749
Received: 15 January 2021 / Revised: 9 February 2021 / Accepted: 19 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Recent Advances in Nutrition and Diabetes)
The purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m2) received a continuous remote care intervention focused on reducing hyperglycemia through carbohydrate restricted nutrition therapy for two years in a single arm, prospective, longitudinal pilot study. Two-year retention was 75% (72 of 96 participants). Fifty-one percent of participants (49 of 96) met carbohydrate restriction goals as assessed by blood beta-hydroxybutyrate concentrations for more than one-third of reported measurements. Estimated cumulative incidence of normoglycemia (HbA1c < 5.7% without medication) and type 2 diabetes (HbA1c ≥ 6.5% or <6.5% with medication other than metformin) at two years were 52.3% and 3%, respectively. Prevalence of metabolic syndrome, class II or greater obesity, and suspected hepatic steatosis significantly decreased at two years. These results demonstrate the potential utility of an alternate approach to type 2 diabetes prevention, carbohydrate restricted nutrition therapy delivered through a continuous remote care model, for normalization of glycemia and improvement in related comorbidities. View Full-Text
Keywords: prediabetes; remote continuous care; low carbohydrate; metabolic syndrome; obesity prediabetes; remote continuous care; low carbohydrate; metabolic syndrome; obesity
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MDPI and ACS Style

McKenzie, A.L.; Athinarayanan, S.J.; McCue, J.J.; Adams, R.N.; Keyes, M.; McCarter, J.P.; Volek, J.S.; Phinney, S.D.; Hallberg, S.J. Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study. Nutrients 2021, 13, 749. https://doi.org/10.3390/nu13030749

AMA Style

McKenzie AL, Athinarayanan SJ, McCue JJ, Adams RN, Keyes M, McCarter JP, Volek JS, Phinney SD, Hallberg SJ. Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study. Nutrients. 2021; 13(3):749. https://doi.org/10.3390/nu13030749

Chicago/Turabian Style

McKenzie, Amy L., Shaminie J. Athinarayanan, Jackson J. McCue, Rebecca N. Adams, Monica Keyes, James P. McCarter, Jeff S. Volek, Stephen D. Phinney, and Sarah J. Hallberg. 2021. "Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study" Nutrients 13, no. 3: 749. https://doi.org/10.3390/nu13030749

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