Next Article in Journal
Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects
Previous Article in Journal
Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
 
 
Article

Vitamin D and Hospital Admission in Older Adults: A Prospective Association

1
Mercers Institute for Research on Ageing, St James’s Hospital, D08 NYH1 Dublin, Ireland
2
Department of Gerontology, St James’s Hospital, D08 NYH1 Dublin, Ireland
3
School of Medicine, Trinity College, D02PN40 Dublin, Ireland
4
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK
5
Department of Biochemistry, St James’s Hospital, D08 NYH1 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Etienne Cavalier
Nutrients 2021, 13(2), 616; https://doi.org/10.3390/nu13020616
Received: 28 January 2021 / Revised: 8 February 2021 / Accepted: 8 February 2021 / Published: 14 February 2021
(This article belongs to the Section Nutritional Epidemiology)
The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adults with hospital admission and emergency department (ED) attendance. Trinity University of Ulster Department of Agriculture (TUDA) is a large cross-sectional study of older adults with a community population from three disease-defined cohorts (cognitive dysfunction, hypertension, and osteoporosis). Participants included in this analysis were recruited between 2008 and 2012. ED and hospital admission data were gathered from the date of TUDA participation until June 2013, with a mean follow up of 3.6 years. Of the 3093 participants, 1577 (50.9%) attended the ED during the period of follow-up. Attendees had lower mean serum 25(OH)D concentrations than non-attendees (59.1 vs. 70.6 nmol/L). Fully adjusted models showed an inverse association between vitamin D and ED attendance (Hazard Ratio (HR) 0.996; 95% Confidence Interval (CI) 0.995–0.998; p < 0.001). A total of 1269 participants (41%) were admitted to hospital during the follow-up. Those admitted had lower mean vitamin D concentrations (58.4 vs. 69.3 nmol/L, p < 0.001). In fully adjusted models, higher vitamin D was inversely associated with hospital admission (HR 0.996; 95% CI 0.994–0.998; p < 0.001) and length of stay (LOS) (β = −0.95, p = 0.006). This study showed independent prospective associations between vitamin D deficiency and increased hospitalisation by older adults. The need for further evaluation of current recommendations in relation to vitamin D supplementation, with consideration beyond bone health, is warranted and should focus on randomised controlled trials. View Full-Text
Keywords: vitamin D; vitamin D deficiency; hospitalisation; hospital admission; emergency department attendance; resource utilisation vitamin D; vitamin D deficiency; hospitalisation; hospital admission; emergency department attendance; resource utilisation
Show Figures

Figure 1

MDPI and ACS Style

Beirne, A.; McCarroll, K.; Walsh, J.B.; Casey, M.; Laird, E.; McNulty, H.; Ward, M.; Hoey, L.; Molloy, A.M.; Healy, M.; Hughes, C.; Strain, S.; Cunningham, C. Vitamin D and Hospital Admission in Older Adults: A Prospective Association. Nutrients 2021, 13, 616. https://doi.org/10.3390/nu13020616

AMA Style

Beirne A, McCarroll K, Walsh JB, Casey M, Laird E, McNulty H, Ward M, Hoey L, Molloy AM, Healy M, Hughes C, Strain S, Cunningham C. Vitamin D and Hospital Admission in Older Adults: A Prospective Association. Nutrients. 2021; 13(2):616. https://doi.org/10.3390/nu13020616

Chicago/Turabian Style

Beirne, Avril, Kevin McCarroll, James Bernard Walsh, Miriam Casey, Eamon Laird, Helene McNulty, Mary Ward, Leane Hoey, Anne M. Molloy, Martin Healy, Catherine Hughes, Sean Strain, and Conal Cunningham. 2021. "Vitamin D and Hospital Admission in Older Adults: A Prospective Association" Nutrients 13, no. 2: 616. https://doi.org/10.3390/nu13020616

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop