Next Article in Journal
L-Arginine Reduces Nitro-Oxidative Stress in Cultured Cells with Mitochondrial Deficiency
Previous Article in Journal
The Effectiveness of Supportive Psychotherapy in Weight Loss in a Group of Young Overweight and Obese Women
Article

Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood

1
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland
2
Centre for Population Health Research, Turku University Hospital, University of Turku, 20520 Turku, Finland
3
Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, 20520 Turku, Finland
4
Heart Center, Turku University Hospital, University of Turku, 20520 Turku, Finland
5
Department of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, 20520 Turku, Finland
6
Department of Public Health, Turku University Hospital, University of Turku, 20520 Turku, Finland
7
Division of Medicine, Department of Medicine, Turku University Hospital, University of Turku, 20520 Turku, Finland
8
Department of Chronic Disease Prevention, Institute for Health and Welfare, 20750 Turku, Finland
9
Computational Medicine, Faculty of Medicine, University of Oulu & Biocenter Oulu, 90014 Oulu, Finland
10
NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland
11
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, 20520 Turku, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Hans Demmelmair
Nutrients 2021, 13(2), 533; https://doi.org/10.3390/nu13020533
Received: 14 January 2021 / Revised: 28 January 2021 / Accepted: 2 February 2021 / Published: 6 February 2021
(This article belongs to the Section Clinical Nutrition)
The Special Turku Coronary Risk Factor Intervention Project (STRIP) is a prospective infancy-onset randomized dietary intervention trial targeting dietary fat quality and cholesterol intake, and favoring consumption of vegetables, fruit, and whole-grains. Diet (food records) and circulating metabolites were studied at six time points between the ages of 9–19 years (n = 549–338). Dietary targets for this study were defined as (1) the ratio of saturated fat (SAFA) to monounsaturated and polyunsaturated fatty acids (MUFA + PUFA) < 1:2, (2) intake of SAFA < 10% of total energy intake, (3) fiber intake ≥ 80th age-specific percentile, and (4) sucrose intake ≤ 20th age-specific percentile. Metabolic biomarkers were quantified by high-throughput nuclear magnetic resonance metabolomics. Better adherence to the dietary targets, regardless of study group allocation, was assoiated with higher serum proportion of PUFAs, lower serum proportion of SAFAs, and a higher degree of unsaturation of fatty acids. Achieving ≥ 1 dietary target resulted in higher low-density lipoprotein (LDL) particle size, lower circulating LDL subclass lipid concentrations, and lower circulating lipid concentrations in medium and small high-density lipoprotein subclasses compared to meeting 0 targets. Attaining more dietary targets (≥2) was associated with a tendency to lower lipid concentrations of intermediate-density lipoprotein and very low-density lipoprotein subclasses. Thus, adherence to dietary targets is favorably associated with multiple circulating fatty acids and lipoprotein subclass lipid concentrations, indicative of better cardio-metabolic health. View Full-Text
Keywords: diet; quality of diet; metabolomics; metabolic profiling; primordial prevention diet; quality of diet; metabolomics; metabolic profiling; primordial prevention
Show Figures

Graphical abstract

MDPI and ACS Style

Lehtovirta, M.; Matthews, L.A.; Laitinen, T.T.; Nuotio, J.; Niinikoski, H.; Rovio, S.P.; Lagström, H.; Viikari, J.S.A.; Rönnemaa, T.; Jula, A.; Ala-Korpela, M.; Raitakari, O.T.; Pahkala, K. Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood. Nutrients 2021, 13, 533. https://doi.org/10.3390/nu13020533

AMA Style

Lehtovirta M, Matthews LA, Laitinen TT, Nuotio J, Niinikoski H, Rovio SP, Lagström H, Viikari JSA, Rönnemaa T, Jula A, Ala-Korpela M, Raitakari OT, Pahkala K. Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood. Nutrients. 2021; 13(2):533. https://doi.org/10.3390/nu13020533

Chicago/Turabian Style

Lehtovirta, Miia, Laurie A. Matthews, Tomi T. Laitinen, Joel Nuotio, Harri Niinikoski, Suvi P. Rovio, Hanna Lagström, Jorma S.A. Viikari, Tapani Rönnemaa, Antti Jula, Mika Ala-Korpela, Olli T. Raitakari, and Katja Pahkala. 2021. "Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood" Nutrients 13, no. 2: 533. https://doi.org/10.3390/nu13020533

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop