Next Article in Journal
Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis
Next Article in Special Issue
Effects of Dietary Oat Beta-Glucans on Colon Apoptosis and Autophagy through TLRs and Dectin-1 Signaling Pathways—Crohn’s Disease Model Study
Previous Article in Journal
Effects of High Glucose and Lipotoxicity on Diabetic Podocytes
Previous Article in Special Issue
Low Molecular Weight Barley β-Glucan Affects Glucose and Lipid Metabolism by Prebiotic Effects
Open AccessReview

Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review

1
Research and Development Laboratories, Fujicco, Co., Ltd., 6-13-4 Minatojima-Nakamachi, Chuo-ku, Kobe, Hyogo 650-8558, Japan
2
Aureo Co., Ltd., 54-1, Kazusa Koito, Kimitsu-shi, Chiba 292-1149, Japan
3
Research and Development Division, Itochu Sugar Co., Ltd., 3, Tamatsuura, Hekinan, Aichi 447-8506, Japan
4
Innovation Center, Osaka Soda Co., Ltd., 9, Otakasu-cho, Amagasaki, Hyogo 660-0842, Japan
5
Life Science Materials Laboratory, ADEKA Corporation., 7-2-34, Higashi-Ogu, Arakawa-ku, Tokyo 116-8553, Japan
6
Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan
*
Authors to whom correspondence should be addressed.
Nutrients 2021, 13(1), 242; https://doi.org/10.3390/nu13010242
Received: 14 December 2020 / Revised: 10 January 2021 / Accepted: 13 January 2021 / Published: 16 January 2021
(This article belongs to the Special Issue Beta-Glucan in Foods and Health Benefits)
The black yeast Aureobasidium pullulans produces abundant soluble β-1,3-1,6-glucan—a functional food ingredient with known health benefits. For use as a food material, soluble β-1,3-1,6-glucan is produced via fermentation using sucrose as the carbon source. Various functionalities of β-1,3-1,6-glucan have been reported, including its immunomodulatory effect, particularly in the intestine. It also exhibits antitumor and antimetastatic effects, alleviates influenza and food allergies, and relieves stress. Moreover, it reduces the risk of lifestyle-related diseases by protecting the intestinal mucosa, reducing fat, lowering postprandial blood glucose, promoting bone health, and healing gastric ulcers. Furthermore, it induces heat shock protein 70. Clinical studies have reported the antiallergic and triglyceride-reducing effects of β-1,3-1,6-glucan, which are indicators of improvement in lifestyle-related diseases. The primary and higher-order structures of β-1,3-1,6-glucan have been elucidated. Specifically, it comprises a single highly-branched glucose residue with the β-1,6 bond (70% or more) on a backbone of glucose with 1,3-β bonds. β-Glucan shows a triple helical structure, and studies on its use as a drug delivery system have been actively conducted. β-Glucan in combination with anti-inflammatory substances or fullerenes can be used to target macrophages. Based on its health functionality, β-1,3-1,6-glucan is an interesting material as both food and medicine. View Full-Text
Keywords: Autreobasidium pullulans; β-1,3-1,6-glucan; physiological function Autreobasidium pullulans; β-1,3-1,6-glucan; physiological function
Show Figures

Graphical abstract

MDPI and ACS Style

Suzuki, T.; Kusano, K.; Kondo, N.; Nishikawa, K.; Kuge, T.; Ohno, N. Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review. Nutrients 2021, 13, 242. https://doi.org/10.3390/nu13010242

AMA Style

Suzuki T, Kusano K, Kondo N, Nishikawa K, Kuge T, Ohno N. Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review. Nutrients. 2021; 13(1):242. https://doi.org/10.3390/nu13010242

Chicago/Turabian Style

Suzuki, Toshio; Kusano, Kisato; Kondo, Nobuhiro; Nishikawa, Kouji; Kuge, Takao; Ohno, Naohito. 2021. "Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review" Nutrients 13, no. 1: 242. https://doi.org/10.3390/nu13010242

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop