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Article

Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer

1
Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland
2
Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland
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Department of General Surgery, Faculty of Medical Sciences, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland
4
Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University and Research, 6700 AH Wageningen, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 200; https://doi.org/10.3390/nu13010200
Received: 9 November 2020 / Revised: 2 January 2021 / Accepted: 7 January 2021 / Published: 11 January 2021
Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms underlying CRC might be the vitamin D pathway, as CRC is the most closely linked neoplasia to vitamin D deficiency. This study shows a possible association of the vitamin D receptor (VDR) polymorphisms FokI, BsmI, ApaI, and TaqI with CRC susceptibility. A total of 103 patients diagnosed with CRC (61 men and 42 women, aged 57–82 years) and 109 healthy people (50 men and 59 women, aged 47–68 years) were genotyped using PCR-RFLP for FokI, BsmI, ApaI, and TaqI. None of the single nucleotide polymorphisms (SNPs) individually increased or decreased the risk of CRC. The evaluation of haplotypes revealed two that might enhance the likelihood of CRC development: taB (OR = 30.22; 95% CI 2.81–325.31; p = 0.01) and tAb (OR = 3.84; 95% CI 1.29–11.38; p = 0.01). In conclusion, genotyping is an easy and robust procedure that needs to be performed only once in a lifetime. A creation of a relevant SNP’s panel might contribute to the identification of the groups that are at the greatest risk of CRC. View Full-Text
Keywords: vitamin D; vitamin D receptor; colorectal cancer; single nucleotide polymorphism (SNP); ApaI; TaqI; FokI; BsmI vitamin D; vitamin D receptor; colorectal cancer; single nucleotide polymorphism (SNP); ApaI; TaqI; FokI; BsmI
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MDPI and ACS Style

Latacz, M.; Rozmus, D.; Fiedorowicz, E.; Snarska, J.; Jarmołowska, B.; Kordulewska, N.; Savelkoul, H.; Cieślińska, A. Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer. Nutrients 2021, 13, 200. https://doi.org/10.3390/nu13010200

AMA Style

Latacz M, Rozmus D, Fiedorowicz E, Snarska J, Jarmołowska B, Kordulewska N, Savelkoul H, Cieślińska A. Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer. Nutrients. 2021; 13(1):200. https://doi.org/10.3390/nu13010200

Chicago/Turabian Style

Latacz, Maria, Dominika Rozmus, Ewa Fiedorowicz, Jadwiga Snarska, Beata Jarmołowska, Natalia Kordulewska, Huub Savelkoul, and Anna Cieślińska. 2021. "Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer" Nutrients 13, no. 1: 200. https://doi.org/10.3390/nu13010200

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