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Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers

1
Department of Neonatology, Medical University of Warsaw, 02-091 Warsaw, Poland
2
First Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland
3
Department of Immunology, Transplant Medicine and Internal Diseases, Transplantation Institute, Medical University of Warsaw, 02-014 Warsaw, Poland
4
Department of Bioinformatics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland
5
Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland
6
Institute of Genetics and Biotechnology, Biology Department, Warsaw University, 02-106 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2713; https://doi.org/10.3390/nu12092713
Received: 1 July 2020 / Revised: 19 August 2020 / Accepted: 31 August 2020 / Published: 4 September 2020
(This article belongs to the Section Nutrition Methodology & Assessment)
The rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by measuring the concentration of cyclosporine and its metabolites in the colostrum of seven post-transplant mothers. The mean concentration of cyclosporine in the colostrum was 22.40 ± 9.43 mcg/L, and the estimated mean daily dose of the drug was 1049.22 ± 397.41 ng/kg/24 h. Only three metabolites (AM1, DHCsA, and THCsA) had mean colostrum amounts comparable to or higher than cyclosporine itself, with the daily doses being 468.51 ± 80.37, 2757.79 ± 1926.11, and 1044.76 ± 948.56 ng/kg/24 h, respectively. Our results indicate a low transfer of cyclosporine and its metabolites into the colostrum in the first two days postpartum and confirm the emerging change to the policy on breastfeeding among post-transplant mothers. A full assessment of the safety of immunosuppressant exposure via breastmilk will require further studies with long-term follow-ups of breastfed children. View Full-Text
Keywords: breastfeeding; immunosuppression; cyclosporine A; transplant; lactation breastfeeding; immunosuppression; cyclosporine A; transplant; lactation
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MDPI and ACS Style

Kociszewska-Najman, B.; Mazanowska, N.; Borek-Dzięcioł, B.; Pączek, L.; Samborowska, E.; Szpotańska-Sikorska, M.; Pietrzak, B.; Dadlez, M.; Wielgoś, M. Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers. Nutrients 2020, 12, 2713. https://doi.org/10.3390/nu12092713

AMA Style

Kociszewska-Najman B, Mazanowska N, Borek-Dzięcioł B, Pączek L, Samborowska E, Szpotańska-Sikorska M, Pietrzak B, Dadlez M, Wielgoś M. Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers. Nutrients. 2020; 12(9):2713. https://doi.org/10.3390/nu12092713

Chicago/Turabian Style

Kociszewska-Najman, Bożena, Natalia Mazanowska, Beata Borek-Dzięcioł, Leszek Pączek, Emilia Samborowska, Monika Szpotańska-Sikorska, Bronisława Pietrzak, Michał Dadlez, and Mirosław Wielgoś. 2020. "Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers" Nutrients 12, no. 9: 2713. https://doi.org/10.3390/nu12092713

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