Next Article in Journal
A Call to Action: Now Is the Time to Screen Elderly and Treat Osteosarcopenia, a Position Paper of the Italian College of Academic Nutritionists MED/49 (ICAN-49)
Next Article in Special Issue
Inhibition of Mg2+ Extrusion Attenuates Glutamate Excitotoxicity in Cultured Rat Hippocampal Neurons
Previous Article in Journal
Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review
Previous Article in Special Issue
Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness
 
 
Review

Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate

1
Dipartimento di Scienze Biomediche e Cliniche L. Sacco, Università di Milano, 20157 Milano, Italy
2
Department of Clinical Pharmacology, University Hospital and Inserm 1107 Fundamental and Clinical Pharmacology of Pain, Medical Faculty, F-63000 Clermont-Ferrand, France
3
Sanofi Consumer Health Care, 20158 Milan, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2660; https://doi.org/10.3390/nu12092660
Received: 23 June 2020 / Revised: 13 August 2020 / Accepted: 21 August 2020 / Published: 31 August 2020
(This article belongs to the Special Issue Magnesium in Human Health and Disease)
Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines. View Full-Text
Keywords: magnesium; pidolate; deficiency; headache; migraine; BBB magnesium; pidolate; deficiency; headache; migraine; BBB
Show Figures

Graphical abstract

MDPI and ACS Style

Maier, J.A.; Pickering, G.; Giacomoni, E.; Cazzaniga, A.; Pellegrino, P. Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate. Nutrients 2020, 12, 2660. https://doi.org/10.3390/nu12092660

AMA Style

Maier JA, Pickering G, Giacomoni E, Cazzaniga A, Pellegrino P. Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate. Nutrients. 2020; 12(9):2660. https://doi.org/10.3390/nu12092660

Chicago/Turabian Style

Maier, Jeanette A., Gisele Pickering, Elena Giacomoni, Alessandra Cazzaniga, and Paolo Pellegrino. 2020. "Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate" Nutrients 12, no. 9: 2660. https://doi.org/10.3390/nu12092660

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop