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Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy

Pediatric Gastroenterology Department, Paris-Descartes University, 75006 Paris, France
Pediatric Gastroenterology Department, APHP Necker-Enfants Malades Hospital, 750015 Paris, France
Marcel Sembat Clinic, 92100 Boulogne, France
Association Française de Pédiatrie Ambulatoire (French Association of Ambulatory Paediatrics), 33400 Talence, France
Medical and Pharmacy School, Franche-Comté University, 25000 Besançon, France
UMR Nutrition Physiology and Ingestive Behavior, AgroParisTech, INRA, Paris-Saclay University, 75005 Paris, France
Charles Nicolle Hospital, 76031 Rouen, France
Pediatric Allergy Department, Children’s Hospital, University Hospital of Nancy, 54000 Vandoeuvre les Nancy, France
Sodilac Employee, Sodilac, 92000 Levallois, France
Pediatric Practice, 16 Rue de Sept Fonds, 81000 Albi, France
Medical General and Allergy Practice, 67400 Illkirch Graffenstaden, France
Paediatric Allergy Research Group, Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, London WC2R ELS, UK
INSERM-U1185, Paris Sud Paris-Saclay University, 75005 Paris, France
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, Network OSCAR and ‘Platform of Expertise Paris Sud for Rare Diseases, 75005 Paris, France
APHP, Endocrinology and Diabetes for Children, 75005 Paris, France
Pediatric Practice, 69006 Lyon, France
Department of Dermatology and Pediatric Dermatology, Bordeaux University Hospital, 33000 Bordeaux, France
Department of Paediatrics, Saint Antoine Paediatric Hospital, Saint Vincent de Paul Hospital, Groupement des Hôpitaux de l’Institut Catholique de Lille (GHICL), Catholic University of Lille, 59000 Lille, France
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2654;
Received: 30 June 2020 / Revised: 20 August 2020 / Accepted: 25 August 2020 / Published: 31 August 2020
Formulas adapted to infant feeding, although most of the time made from cow’s milk proteins, can be made from hydrolyzed rice protein but they must be classified as “formulas for specific medical needs”, according to European regulations. The nutritional quality of rice proteins is thus suitable to be used in infant formulas giving that it is supplemented by certain amino acids which can be lacking. Besides, hydrolysis is required to facilitate their water solubility and digestibility. Owing to a low allergenicity of rice and to the absence of the cross-allergy between milk proteins and rice proteins, these formulas are adapted to the diet of children with cow’s milk protein allergy (CMPA), which explains their growing use in some countries. However, CMPA, an expanding disorder, has consequences for growth, bone mineralization, and often has an association with allergy to other foods, including cow’s milk extensive hydrolysate, so that a surveillance of the adaption of hydrolyzed rice protein formulas (HRPF) to CMPA, the absence of unexpected side effects, and the appropriate response to its various health hazards seems mandatory. This paper analyses the health problem deriving from CMPA, the industrial development of hydrolyzed rice protein formulas, and the limited number of clinical studies, which confirms, at the moment, a good allergic tolerance and safety. The goal is to better advise heath care professionals on their use of HRPFs during CMPA. View Full-Text
Keywords: children; rice; hydrolyzed protein; cow’s milk allergy children; rice; hydrolyzed protein; cow’s milk allergy
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MDPI and ACS Style

Dupont, C.; Bocquet, A.; Tomé, D.; Bernard, M.; Campeotto, F.; Dumond, P.; Essex, A.; Frelut, M.-L.; Guénard-Bilbault, L.; Lack, G.; Linglart, A.; Payot, F.; Taieb, A.; Kalach, N. Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy. Nutrients 2020, 12, 2654.

AMA Style

Dupont C, Bocquet A, Tomé D, Bernard M, Campeotto F, Dumond P, Essex A, Frelut M-L, Guénard-Bilbault L, Lack G, Linglart A, Payot F, Taieb A, Kalach N. Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy. Nutrients. 2020; 12(9):2654.

Chicago/Turabian Style

Dupont, Christophe, Alain Bocquet, Daniel Tomé, Marie Bernard, Florence Campeotto, Pascale Dumond, Anna Essex, Marie-Laure Frelut, Lydie Guénard-Bilbault, Gideon Lack, Agnès Linglart, François Payot, Alain Taieb, and Nicolas Kalach. 2020. "Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow’s Milk Allergy" Nutrients 12, no. 9: 2654.

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