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Optimisation and Validation of a Nutritional Intervention to Enhance Sleep Quality and Quantity

School of Behavioural and Health Sciences, Australian Catholic University, Banyo QLD 4014, Australia
High Performance Unit, Swimming Australia, Brisbane QLD 4519, Australia
Rowing Australia, Yarralumla ACT 2600, Australia
Appleton Institute for Behavioural Science, Central Queensland University, Wayville 5034, Australia
Gatorade Sport Science Institute, PepsiCo Global Research and Development-Life Sciences, Purchase, NY 10577, USA
Departments of Neurobiology, Physiology & Behavior and Department of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95817, USA
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2579;
Received: 7 July 2020 / Revised: 19 August 2020 / Accepted: 20 August 2020 / Published: 25 August 2020
(This article belongs to the Section Nutrition and Public Health)
Background: Disturbed sleep may negatively influence physical health, cognitive performance, metabolism, and general wellbeing. Nutritional interventions represent a potential non-pharmacological means to increase sleep quality and quantity. Objective: (1) Identify an optimal suite of nutritional ingredients and (2) validate the effects of this suite utilising polysomnography, and cognitive and balance tests. Methods: The optimal and least optimal combinations of six ingredients were identified utilising 55 male participants and a Box–Behnken predictive model. To validate the model, 18 healthy, male, normal sleepers underwent three trials in a randomised, counterbalanced design: (1) optimal drink, (2) least optimal drink, or (3) placebo were provided before bed in a double-blinded manner. Polysomnography was utilised to measure sleep architecture. Cognitive performance, postural sway, and subjective sleep quality, were assessed 30 min after waking. Results: The optimal drink resulted in a significantly shorter sleep onset latency (9.9 ± 12.3 min) when compared to both the least optimal drink (26.1 ± 37.4 min) and the placebo drink (19.6 ± 32.0 min). No other measures of sleep, cognitive performance, postural sway, and subjective sleep quality were different between trials. Conclusion: A combination of ingredients, optimised to enhance sleep, significantly reduced sleep onset latency. No detrimental effects on sleep architecture, subjective sleep quality or next day performance were observed. View Full-Text
Keywords: nutrition; polysomnography; sleep onset latency nutrition; polysomnography; sleep onset latency
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MDPI and ACS Style

Halson, S.L.; Shaw, G.; Versey, N.; Miller, D.J.; Sargent, C.; Roach, G.D.; Nyman, L.; Carter, J.M.; Baar, K. Optimisation and Validation of a Nutritional Intervention to Enhance Sleep Quality and Quantity. Nutrients 2020, 12, 2579.

AMA Style

Halson SL, Shaw G, Versey N, Miller DJ, Sargent C, Roach GD, Nyman L, Carter JM, Baar K. Optimisation and Validation of a Nutritional Intervention to Enhance Sleep Quality and Quantity. Nutrients. 2020; 12(9):2579.

Chicago/Turabian Style

Halson, Shona L., Gregory Shaw, Nathan Versey, Dean J. Miller, Charli Sargent, Gregory D. Roach, Lara Nyman, James M. Carter, and Keith Baar. 2020. "Optimisation and Validation of a Nutritional Intervention to Enhance Sleep Quality and Quantity" Nutrients 12, no. 9: 2579.

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