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Open AccessArticle

Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India
Institute of Genetics and Animal Biotechnology Polish Academy of Sciences, 05-552 Magdalenka, Poland
Division of Medical Biology, Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland
Department of Surgical Medicine with the Laboratory of Medical Genetics, Collegium Medicum, Jan Kochanowski University, al. IX Wieków Kielc 19A, 25-317 Kielce, Poland
Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, 01-815 Warsaw, Poland
Department of Technique and Food Product Development, Warsaw University of Life Sciences (WULS-SGGW) 159c Nowoursynowska, 02-776 Warsaw, Poland
Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev str., 1113 Sofia, Bulgaria
Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2552;
Received: 6 July 2020 / Revised: 17 August 2020 / Accepted: 19 August 2020 / Published: 24 August 2020
(This article belongs to the Special Issue Nutrition and Diet in Metabolic Syndrome)
Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant (p < 0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice. View Full-Text
Keywords: fenugreek; aging; liver; antioxidants; mice fenugreek; aging; liver; antioxidants; mice
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Tewari, D.; Jóźwik, A.; Łysek-Gładysińska, M.; Grzybek, W.; Adamus-Białek, W.; Bicki, J.; Strzałkowska, N.; Kamińska, A.; Horbańczuk, O.K.; Atanasov, A.G. Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice. Nutrients 2020, 12, 2552.

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