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The Association between Omega-3 Fatty Acid Intake and Human Brain Connectivity in Middle-Aged Depressed Women

1
Department of Food and Nutrition, College of BioNano Technology, Gachon University, Gyeonggi 13120, Korea
2
Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea
3
Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon 21936, Korea
4
Department of Psychiatry, Gachon University Gil Medical Center, Incheon 21565, Korea
5
Research Group of Functional Food Materials, Korea Food Research Institute, Wanju 55365, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally in this study.
Nutrients 2020, 12(8), 2191; https://doi.org/10.3390/nu12082191
Received: 24 June 2020 / Revised: 21 July 2020 / Accepted: 21 July 2020 / Published: 23 July 2020
(This article belongs to the Section Macronutrients and Human Health)
Omega-3 fatty acid (n-3 FA) intake is known to have a preventive effect on depressive symptoms in a general population. This study assessed the effects of n-3 FA intake on depressive symptoms and brain function in middle-aged women. Depressive symptoms were screened using the Beck Depression Inventory-II (BDI-II) and Center for Epidemiologic Studies-Depression scale (CES-D) assessment questionnaires, and n-3 FA intakes were assessed using semiquantitative food frequency questionnaire. We found that n-3 FA intakes were negatively associated with depressive symptoms in middle-aged women. Psychiatrists diagnosed the presence of depressive disorders using the 5th edition of the Mental Disorder Diagnosis and Statistics Manual (DSM-5). Resting-state functional magnetic resonance imaging (rs-fMRI) was performed to investigate the association between n-3 FA intake and brain functional connectivity. Functional connectivity of the right middle frontal cortex (default mode network) and the right middle temporal pole (frontoparietal network) was positively associated with depressive symptom scores and negatively associated with n-3 FA intakes. In conclusion, high n-3 FA intake decreases the risk of depressive symptoms and modifies the brain functional connectivity in middle-aged women. View Full-Text
Keywords: depression; omega-3 fatty acid; resting-state functional MRI; middle-aged women depression; omega-3 fatty acid; resting-state functional MRI; middle-aged women
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Park, S.-J.; Lee, D.-K.; Kim, B.; Na, K.-S.; Lee, C.-H.; Son, Y.-D.; Lee, H.-J. The Association between Omega-3 Fatty Acid Intake and Human Brain Connectivity in Middle-Aged Depressed Women. Nutrients 2020, 12, 2191.

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