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The Impact of Protein Supplementation Targeted at Improving Muscle Mass on Strength in Cancer Patients: A Scoping Review

Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy
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Nutrients 2020, 12(7), 2099; https://doi.org/10.3390/nu12072099
Received: 22 May 2020 / Revised: 15 June 2020 / Accepted: 3 July 2020 / Published: 16 July 2020
Deterioration of muscle strength during cancer results in functional limitation, poor quality of life and reduced survival. The indirect effects on muscle strength of nutritional interventions based on protein and amino acid derivatives targeted at improving muscle mass are poorly documented. A scoping review was performed to examine the available evidence on the effects of proteins, amino acids and their derivatives on muscle strength in adult cancer patients. Pubmed and Scopus databases were searched to identify research articles published in the last 10 years. Fourteen studies met the inclusion criteria, showing that changes in muscle strength following protein or amino acid supplementation are generally concordant with those in muscle mass in cancer patients. Administration of both energy and proteins in the presence of reduced oral intakes results in more robust effects on both muscle strength and mass. It is not clear whether this is due to the correction of the energy deficit or to an interaction between proteins and other macronutrients. The optimal mixture, type, and dose of amino acid/protein supplementation alone or in combination with other anabolic strategies should be determined to provide the best nutritional approach in cancer. View Full-Text
Keywords: amino acids supplementation; cancer; handgrip; muscle strength; protein supplementation; scoping review amino acids supplementation; cancer; handgrip; muscle strength; protein supplementation; scoping review
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MDPI and ACS Style

Zanetti, M.; Gortan Cappellari, G.; Barazzoni, R.; Sanson, G. The Impact of Protein Supplementation Targeted at Improving Muscle Mass on Strength in Cancer Patients: A Scoping Review. Nutrients 2020, 12, 2099. https://doi.org/10.3390/nu12072099

AMA Style

Zanetti M, Gortan Cappellari G, Barazzoni R, Sanson G. The Impact of Protein Supplementation Targeted at Improving Muscle Mass on Strength in Cancer Patients: A Scoping Review. Nutrients. 2020; 12(7):2099. https://doi.org/10.3390/nu12072099

Chicago/Turabian Style

Zanetti, Michela, Gianluca Gortan Cappellari, Rocco Barazzoni, and Gianfranco Sanson. 2020. "The Impact of Protein Supplementation Targeted at Improving Muscle Mass on Strength in Cancer Patients: A Scoping Review" Nutrients 12, no. 7: 2099. https://doi.org/10.3390/nu12072099

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