Next Article in Journal
Effects of L-Phenylalanine on Energy Intake and Glycaemia—Impacts on Appetite Perceptions, Gastrointestinal Hormones and Gastric Emptying in Healthy Males
Previous Article in Journal
Usual Dietary Intake, Nutritional Adequacy and Food Sources of Calcium, Phosphorus, Magnesium and Vitamin D of Spanish Children Aged One to <10 Years. Findings from the EsNuPI Study
Article

SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana

1
Department Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany
2
Research Group Molecular Nutritional Medicine, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany
3
Department of Endocrinology, Diabetes and Nutrition, Charité—Universitaetsmedizin Berlin, 13125 Berlin, Germany
4
German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany
5
Junior Research Group ProAID, Institute of Nutritional Science, Potsdam University, 14558 Nuthetal, Germany
6
Physiology and Pathophysiology of Nutrition, Institute of Nutrition Science, Potsdam University, 14558 Nuthetal, Germany
7
Komfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology (KNUST), P.O. Box 1934 Kumasi, Ghana
8
Agogo Presbyterian Hospital, P.O. Box 27 Agogo, Ghana
9
Institute of Tropical Medicine and International Health, Charité—Universitaetsmedizin Berlin, 13353 Berlin, Germany
10
Heidelberg Institute of Global Health (HIGH), Universitaetsklinikum Heidelberg, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1786; https://doi.org/10.3390/nu12061786
Received: 18 April 2020 / Revised: 10 June 2020 / Accepted: 12 June 2020 / Published: 16 June 2020
(This article belongs to the Section Micronutrients and Human Health)
In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A carotenoids is essential. Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a vitamin A deficiency (defined as plasma retinol < 0.7 µmol/L). Hence, the aim of this cross-sectional study was to identify the relationships between variants in the β-carotene 15,15’-oxygenase (BCO1) gene and plasma carotenoid concentrations among 189 15-year-old girls and boys in rural Ghana. BCO1 rs6564851, rs7500996, rs10048138 and PKD1L2 rs6420424, and rs8044334 were typed, and carotenoid concentrations were compared among the different genotypes. G allele carriers of rs6564851 (53%) showed higher plasma carotenoid concentrations than T allele carriers (median (interquartile range): 3.07 (2.17–4.02) vs. 2.59 (2.21–3.50) µmol/L, p-value = 0.0424). This was not explained by differences in socio-demographic or dietary factors. In contrast, no differences in plasma retinol concentrations were observed between these genotypes. Pending verification in independent populations, the low conversion efficiency of provitamin A carotenoids among rs6564851 G allele carriers may undermine existing fortification and supplementation programs to improve the vitamin A status in sub-Saharan Africa. View Full-Text
Keywords: carotenoids; vitamin A deficiency; single nucleotide polymorphism; BCO1; Ghana carotenoids; vitamin A deficiency; single nucleotide polymorphism; BCO1; Ghana
Show Figures

Figure 1

MDPI and ACS Style

Graßmann, S.; Pivovarova-Ramich, O.; Henze, A.; Raila, J.; Ampem Amoako, Y.; King Nyamekye, R.; Bedu-Addo, G.; Mockenhaupt, F.P.; Schulze, M.B.; Danquah, I. SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana. Nutrients 2020, 12, 1786. https://doi.org/10.3390/nu12061786

AMA Style

Graßmann S, Pivovarova-Ramich O, Henze A, Raila J, Ampem Amoako Y, King Nyamekye R, Bedu-Addo G, Mockenhaupt FP, Schulze MB, Danquah I. SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana. Nutrients. 2020; 12(6):1786. https://doi.org/10.3390/nu12061786

Chicago/Turabian Style

Graßmann, Sophie, Olga Pivovarova-Ramich, Andrea Henze, Jens Raila, Yaw Ampem Amoako, Richard King Nyamekye, George Bedu-Addo, Frank P. Mockenhaupt, Matthias B. Schulze, and Ina Danquah. 2020. "SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana" Nutrients 12, no. 6: 1786. https://doi.org/10.3390/nu12061786

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop