Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn’s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways
by
Tamara Ortiz 1,*
, Federico Argüelles-Arias 2,3, Matilde Illanes 1, Josefa-María García-Montes 2, Elena Talero 4, Laura Macías-García 1, Ana Alcudia 5, Victoria Vázquez-Román 1, Virginia Motilva 4 and Manuel De-Miguel 1,*
Tamara Ortiz 1,*, Federico Argüelles-Arias 2,3, Matilde Illanes 1, Josefa-María García-Montes 2, Elena Talero 4, Laura Macías-García 1, Ana Alcudia 5, Victoria Vázquez-Román 1, Virginia Motilva 4 and Manuel De-Miguel 1,*
1
Department of Normal and Pathological Cytology and Histology, University of Seville, Avda. Sánchez-Pizjuán s/n, 41009 Sevilla, Spain
2
Department of Medicine, University of Seville, Avda. Sánchez-Pizjuán s/n, 41009 Sevilla, Spain
3
Department of Gastroenterology, University Hospital Virgen Macarena, c/Dr. Fedriani, nº 3, 41009 Sevilla, Spain
4
Department of Pharmacology, University of Seville, c/Prof García González, nº 2, 41012 Sevilla, Spain
5
Department of Organic and Pharmaceutical Chemistry, University of Seville, c/Prof García González, nº 2, 41012 Sevilla, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1752; https://doi.org/10.3390/nu12061752
Received: 1 May 2020 / Revised: 9 June 2020 / Accepted: 9 June 2020 / Published: 11 June 2020
(This article belongs to the Special Issue Polyphenol-Rich Foods for Human Health)
Nutraceuticals include a wide variety of bioactive compounds, such as polyphenols, which have been highlighted for their remarkable health benefits. Specially, maqui berries have shown great antioxidant activity and anti-inflammatory effects on some inflammatory diseases. The objectives of the present study were to explore the therapeutic effects of maqui berries on acute-phase inflammation in Crohn’s disease. Balb/c mice were exposed to 2,4,6-trinitrobenzene sulfonic acid (TNBS) via intracolonic administration. Polyphenolic maqui extract (Ach) was administered orally daily for 4 days after TNBS induction (Curative Group), and for 7 days prior to the TNBS induction until sacrifice (Preventive Group). Our results showed that both preventive and curative Ach administration inhibited body weight loss and colon shortening, and attenuated the macroscopic and microscopic damage signs, as well as significantly reducing transmural inflammation and boosting the recovery of the mucosal architecture and its muco-secretory function. Additionally, Ach promotes macrophage polarization to the M2 phenotype and was capable of down-regulating significantly the expression of inflammatory proteins COX-2 and iNOS, and at the same time it regulates the antioxidant Nrf-2/HO-1 pathway. In conclusion, this is the first study in which it is demonstrated that the properties of Ach as could be used as a preventive and curative treatment in Crohn’s disease.
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Keywords:
maqui; polyphenols; Crohn’s disease; inflammatory bowel disease; acute inflammation; macrophages; antioxidants; inflammatory proteins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Ortiz, T.; Argüelles-Arias, F.; Illanes, M.; García-Montes, J.-M.; Talero, E.; Macías-García, L.; Alcudia, A.; Vázquez-Román, V.; Motilva, V.; De-Miguel, M. Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn’s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways. Nutrients 2020, 12, 1752.
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