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Open AccessArticle

Vitamin C in Home Parenteral Nutrition: A Need for Monitoring

Nutrition Intensive Care Unit, Hospices Civil de Lyon, CEDEX, F-69495 Pierre Benite, France
CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, CEDEX, 69921 Oullins, France
Department of Gastroenterology, Hospices Civils de Lyon, CEDEX, F-69495 Pierre Benite, France
Biochemistry Department, Lyon Sud Hospital, Hospices Civils de Lyon, F-69495 Pierre Benite, France
Centre Agréé de Nutrition Parentérale à Domicile, Hospices Civils de Lyon, CEDEX, F-69495 Pierre Benite, France
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1667;
Received: 28 April 2020 / Revised: 30 May 2020 / Accepted: 1 June 2020 / Published: 3 June 2020
(This article belongs to the Special Issue Intestinal Failure and Home Parenteral Nutrition)
To date, there are no recommendations about screening plasma vitamin C concentration and adjust its supplementation in patients on long-term home parenteral nutrition (HPN). The aim of this study was to evaluate vitamin C status and determine if a commercial multivitamin preparation (CMVP) containing 125 mg of vitamin C is sufficient in stable patients on HPN. All clinically stable patients receiving HPN or an intravenous fluid infusion at least two times per week for at least 6 months, hospitalized for nutritional assessment, were retrospectively included, for a total of 186 patients. We found that 29% of the patients had vitamin C insufficiency (i.e., <25 µmol/L). In univariate analysis, C-reactive protein (CRP) (p = 0.002) and intake of only 125 mg of vitamin C (p = 0.001) were negatively associated with vitamin C levels, and duration of follow-up in our referral center (p = 0.009) was positively associated with vitamin C levels. In multivariate analysis, only CRP (p = 0.001) and intake of 125 mg of vitamin C (p < 0.0001) were independently associated with low plasma vitamin C concentration. Patients receiving only CMVP with a low plasma vitamin C level significantly received personal compounded HPN (p = 0.008) and presented an inflammatory syndrome (p = 0.002). Vitamin C insufficiency is frequent in individuals undergoing home parenteral nutrition; therefore, there is a need to monitor plasma vitamin C levels, especially in patients on HPN with an inflammatory syndrome and only on CMVP. View Full-Text
Keywords: vitamin C; home parenteral nutrition; commercial multivitamin preparation vitamin C; home parenteral nutrition; commercial multivitamin preparation
MDPI and ACS Style

Grillot, J.; Ait, S.; Bergoin, C.; Couronne, T.; Blond, E.; Peraldi, C.; Barnoud, D.; Chambrier, C.; Lauverjat, M. Vitamin C in Home Parenteral Nutrition: A Need for Monitoring. Nutrients 2020, 12, 1667.

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