The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT

Macher, Susanne; Herster, Cornelia; Holter, Magdalena; Moritz, Martina; Matzhold, Eva Maria; Stojakovic, Tatjana; Pieber, Thomas R.; Schlenke, Peter; Drexler, Camilla; Amrein, Karin

doi:10.3390/nu12051313

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The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT

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Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, 8036 Graz, Austria

Laboratory of the ÖGK, Friedrichgasse 18, 8010 Graz, Austria

Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria

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Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, 8036 Graz, Austria

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Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria

Author to whom correspondence should be addressed.

Nutrients 2020, 12(5), 1313; https://doi.org/10.3390/nu12051313

Received: 31 March 2020 / Revised: 25 April 2020 / Accepted: 30 April 2020 / Published: 5 May 2020

(This article belongs to the Section Micronutrients and Human Health)

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Abstract

Background: Besides anemia, iron deficiency may cause more subtle symptoms, including the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. Objective: The aim of this pre-planned secondary analysis of the IronWoMan randomized controlled trial (RCT) was to compare the frequency and severity of symptoms associated with iron deficiency before and after (intravenous or oral) iron supplementation in iron deficient blood donors. Methods/Design: Prospective, randomized, controlled, single-centre trial. (ClinicalTrials.gov: NCT01787526). Setting: Tertiary care center in Graz, Austria. Participants: 176 (138 female and 38 male) whole-blood and platelet apheresis donors aged ≥ 18 and ≤ 65 years with iron deficiency (ferritin ≤ 30ng/mL at the time of blood donation). Interventions: Intravenous iron (1 g ferric carboxymaltose, n = 86) or oral iron supplementation (10 g iron fumarate, 100 capsules, n = 90). Measurements: Clinical symptoms were evaluated by a survey before iron therapy (visit 0, V0) and after 8–12 weeks (visit 1, V1), including questions about symptoms of restless legs syndrome (RLS), chronic fatigue syndrome (CFS), sleeping disorders, quality of life and symptoms like headaches, dyspnoea, dizziness, palpitations, pica and trophic changes in fingernails or hair. Results: We found a significant improvement in the severity of symptoms for RLS, fatigue and sleep quality (p < 0.001). Furthermore, a significant decrease in headaches, dyspnoea, dizziness and palpitations was reported (p < 0.05). There was no difference between the type of iron supplementation (intravenous versus oral) and clinical outcome data. Conclusion: Iron supplementation in iron-deficient blood donors may be an effective strategy to improve symptoms related to iron deficiency and the wellbeing of blood donors. View Full-Text

Keywords: iron deficiency; blood donor; fatigue; RLS; iron supplementation

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MDPI and ACS Style

Macher, S.; Herster, C.; Holter, M.; Moritz, M.; Matzhold, E.M.; Stojakovic, T.; Pieber, T.R.; Schlenke, P.; Drexler, C.; Amrein, K. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT. Nutrients 2020, 12, 1313. https://doi.org/10.3390/nu12051313

AMA Style

Macher S, Herster C, Holter M, Moritz M, Matzhold EM, Stojakovic T, Pieber TR, Schlenke P, Drexler C, Amrein K. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT. Nutrients. 2020; 12(5):1313. https://doi.org/10.3390/nu12051313

Chicago/Turabian Style

Macher, Susanne, Cornelia Herster, Magdalena Holter, Martina Moritz, Eva Maria Matzhold, Tatjana Stojakovic, Thomas R. Pieber, Peter Schlenke, Camilla Drexler, and Karin Amrein. 2020. "The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT" Nutrients 12, no. 5: 1313. https://doi.org/10.3390/nu12051313

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The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT

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