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Open AccessArticle

Association between Serum Mg2+ Concentrations and Cardiovascular Organ Damage in a Cohort of Adult Subjects

1
Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
2
Department of Clinical and Molecular Medicine, University “Sapienza” of Rome, 00189 Rome, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1264; https://doi.org/10.3390/nu12051264
Received: 27 March 2020 / Revised: 20 April 2020 / Accepted: 25 April 2020 / Published: 29 April 2020
(This article belongs to the Special Issue Carbohydrates, Metabolism and Therapies in Diabetes)
Magnesium (Mg2+) levels are associated with insulin resistance, hypertension, atherosclerosis, and type 2 diabetes (T2DM). We evaluated the clinical utility of physiological Mg2+ in assessing subclinical cardiovascular organ damage including increased carotid artery intima- media thickness (c-IMT) and left ventricular mass index (LVMI) in a cohort of well-characterized adult non-diabetic individuals. Age- and gender-adjusted correlations between Mg2+ and metabolic parameters showed that Mg2+ circulating levels were correlated negatively with body mass index (BMI), fasting glucose, and 2h-oral glucose tolerance test (OGTT) glucose. Similarly, Mg2+ levels were significantly and negatively related to c-IMT and LVMI. A multivariate regression analysis revealed that age (β = 0.440; p < 0.0001), BMI (β = 0.225; p < 0.0001), and Mg2+ concentration (β = −0.122; p < 0.01) were independently associated with c-IMT. Age (β = 0.244; p = 0.012), Mg2+ (β = −0.177; p = 0.019), and diastolic blood pressure (β = 0.184; p = 0.038) were significantly associated with LVMI in women, while age (β = 0.211; p = 0.019), Mg2+ (β = −0.171; p = 0.038) and the homeostasis model assessment index of insulin resistance (HOMA-IR) (β = −0.211; p = 0.041) were the sole variables associated with LVMI in men. In conclusion, our data support the hypothesis that the assessment of Mg2+ as part of the initial work-up might help unravel the presence of subclinical organ damage in subjects at increased risk of cardiovascular complications. View Full-Text
Keywords: magnesium; subclinical atherosclerosis; atherosclerosis; cardiovascular disease; carotid-intima media thickness; left ventricular mass index magnesium; subclinical atherosclerosis; atherosclerosis; cardiovascular disease; carotid-intima media thickness; left ventricular mass index
MDPI and ACS Style

Mancuso, E.; Perticone, M.; Spiga, R.; Averta, C.; Rubino, M.; Fiorentino, T.V.; Miceli, S.; Mannino, G.C.; Sciacqua, A.; Succurro, E.; Perticone, F.; Sesti, G.; Andreozzi, F. Association between Serum Mg2+ Concentrations and Cardiovascular Organ Damage in a Cohort of Adult Subjects. Nutrients 2020, 12, 1264.

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