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Open AccessArticle

Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells

1
Department of Biotechnology, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland
2
Bioorganic Technologies sp. z o.o., Sedziszow Malopolski, Sielec 1A, 39-120 Sielec, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1005; https://doi.org/10.3390/nu12041005
Received: 22 February 2020 / Revised: 30 March 2020 / Accepted: 3 April 2020 / Published: 6 April 2020
More recently, we have proposed a safe non-vector approach to modifying the biochemical profiles of the microalga Planktochlorella nurekis and obtained twelve clones with improved content of lipids and selected pigments and B vitamins and antioxidant activity compared to unaffected cells. In the present study, the biological activity of water and ethanolic extracts of modified clones is investigated in the context of their applications in the cosmetic industry and regenerative medicine. Extract-mediated effects on cell cycle progression, proliferation, migration, mitogenic response, apoptosis induction, and oxidative and nitrosative stress promotion were analyzed in normal human fibroblasts and keratinocytes in vitro. Microalgal extracts did not promote cell proliferation and were relatively non-cytotoxic when short-term treatment was considered. Long-term stimulation with selected microalgal extracts attenuated the development of oxidative stress-induced senescence in skin cells that, at least in part, was correlated with nitric oxide signaling and increased niacin and biotin levels compared to an unmodified microalgal clone. We postulate that selected microalgal extracts of Planktochlorella nurekis can be considered to be used in skin anti-aging therapy. View Full-Text
Keywords: microalgae; Planktochlorella nurekis; skin cells; proliferation; senescence microalgae; Planktochlorella nurekis; skin cells; proliferation; senescence
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Adamczyk-Grochala, J.; Wnuk, M.; Duda, M.; Zuczek, J.; Lewinska, A. Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells. Nutrients 2020, 12, 1005.

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