Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals and Diets
2.2. Blood Biochemical Assays
2.3. Liver Triglycerides Quantification
2.4. Glucose Tolerance and Insulin Resistance Test
2.5. RNA Extraction and Quantitative Real time-Polymerase Chain Reaction (RT-PCR) on Anti-Inflammatory Markers
2.6. Arterial Preparation and Vascular Reactivity Experiments
2.7. Data Analysis and Statistics
3. Results
3.1. POCTA Attenuated Body Weight Gain and Organ Weight in Obese Mice
3.2. POCTA Improved Serum Cholesterol, Triglycerides, Glucose, and Insulin Resistance
3.3. POCTA Reduced the Expression of Inflammatory Markers in White Adipose Tissues
3.4. POCTA Restored Vascular Reactivity in Obese Mice
3.4.1. Vasodilatation
3.4.2. Vasoconstriction
4. Discussion
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Claro-Cala, C.M.; Quintela, J.C.; Pérez-Montero, M.; Miñano, J.; Alvarez de Sotomayor, M.; Herrera, M.D.; Rodríguez-Rodríguez, R. Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice. Nutrients 2020, 12, 323. https://doi.org/10.3390/nu12020323
Claro-Cala CM, Quintela JC, Pérez-Montero M, Miñano J, Alvarez de Sotomayor M, Herrera MD, Rodríguez-Rodríguez R. Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice. Nutrients. 2020; 12(2):323. https://doi.org/10.3390/nu12020323
Chicago/Turabian StyleClaro-Cala, Carmen Maria, Jose Carlos Quintela, Marta Pérez-Montero, Javier Miñano, María Alvarez de Sotomayor, María Dolores Herrera, and Rosalía Rodríguez-Rodríguez. 2020. "Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice" Nutrients 12, no. 2: 323. https://doi.org/10.3390/nu12020323