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Open AccessArticle

Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice

1
Department of Pharmacology, Pediatric and Radiology, Faculty of Medicine, University of Sevilla, E-41009 Sevilla, Spain
2
Natac Biotech S.L., Electrónica 7, 28923 Alcorcón, Madrid, Spain
3
Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Vallès, Spain
4
Departamento de Farmacología, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(2), 323; https://doi.org/10.3390/nu12020323
Received: 20 December 2019 / Revised: 16 January 2020 / Accepted: 22 January 2020 / Published: 26 January 2020
(This article belongs to the Section Nutrition and Metabolism)
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet. View Full-Text
Keywords: pomace olive oil; oleanolic acid; maslinic acid; obesity; Mediterranean diet; vascular function pomace olive oil; oleanolic acid; maslinic acid; obesity; Mediterranean diet; vascular function
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MDPI and ACS Style

Claro-Cala, C.M.; Quintela, J.C.; Pérez-Montero, M.; Miñano, J.; Alvarez de Sotomayor, M.; Herrera, M.D.; Rodríguez-Rodríguez, R. Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice. Nutrients 2020, 12, 323.

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