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The Emerging Role of Vitamin C as a Treatment for Sepsis

1
Department of Internal Medicine, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980050, Richmond, VA 23298, USA
2
Department of Surgery, Division of Acute Care Surgical Services, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980454, Richmond, VA 23298, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 292; https://doi.org/10.3390/nu12020292
Received: 24 December 2019 / Revised: 15 January 2020 / Accepted: 16 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue Vitamin C: From Bench to Bedside)
Sepsis, a life-threatening organ dysfunction due to a dysregulated host response to infection, is a leading cause of morbidity and mortality worldwide. Decades of research have failed to identify any specific therapeutic targets outside of antibiotics, infectious source elimination, and supportive care. More recently, vitamin C has emerged as a potential therapeutic agent to treat sepsis. Vitamin C has been shown to be deficient in septic patients and the administration of high dose intravenous as opposed to oral vitamin C leads to markedly improved and elevated serum levels. Its physiologic role in sepsis includes attenuating oxidative stress and inflammation, improving vasopressor synthesis, enhancing immune cell function, improving endovascular function, and epigenetic immunologic modifications. Multiple clinical trials have demonstrated the safety of vitamin C and two recent studies have shown promising data on mortality improvement. Currently, larger randomized controlled studies are underway to validate these findings. With further study, vitamin C may become standard of care for the treatment of sepsis, but given its safety profile, current treatment can be justified with compassionate use. View Full-Text
Keywords: vitamin C; high-dose intravenous vitamin C; HDIVC; sepsis; septic shock vitamin C; high-dose intravenous vitamin C; HDIVC; sepsis; septic shock
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MDPI and ACS Style

Kashiouris, M.G.; L’Heureux, M.; Cable, C.A.; Fisher, B.J.; Leichtle, S.W.; Fowler, A.A. The Emerging Role of Vitamin C as a Treatment for Sepsis. Nutrients 2020, 12, 292. https://doi.org/10.3390/nu12020292

AMA Style

Kashiouris MG, L’Heureux M, Cable CA, Fisher BJ, Leichtle SW, Fowler AA. The Emerging Role of Vitamin C as a Treatment for Sepsis. Nutrients. 2020; 12(2):292. https://doi.org/10.3390/nu12020292

Chicago/Turabian Style

Kashiouris, Markos G., Michael L’Heureux, Casey A. Cable, Bernard J. Fisher, Stefan W. Leichtle, and Alpha A. Fowler 2020. "The Emerging Role of Vitamin C as a Treatment for Sepsis" Nutrients 12, no. 2: 292. https://doi.org/10.3390/nu12020292

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