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Green Tomato Extract Prevents Bone Loss in Ovariectomized Rats, a Model of Osteoporosis

1
Department of Food Biotechnology, University of Science and Technology, Daejeon 305350, Korea
2
Research Group of Natural Material and Metabolism, Korea Food Research Institute, Wanju 55365, Korea
3
Department of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 02841, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3210; https://doi.org/10.3390/nu12103210
Received: 5 September 2020 / Revised: 6 October 2020 / Accepted: 14 October 2020 / Published: 21 October 2020
(This article belongs to the Section Nutrition and Metabolism)
Although drug therapies are available for postmenopausal osteoporosis, these drugs are not free of side effects and long-term adherence to them are low. A safe and effective nutritional approach to counter postmenopausal osteoporosis is an important research goal. We fed ovariectomized (OVX) Sprague–Dawley rats a diet supplemented with 1% or 2% green tomato extract (GTE). After 12 weeks, micro-computed tomography scans revealed that GTE supplementation effectively prevented distal femur bone loss. This prevention was due to improved bone formation and suppressed bone resorption as observed by the regulation of osteoblast and osteoclast activities. GTE supplementation also improved bone formation through Bmp2-Smad 1/5/8-Runx2 signaling, while bone resorption was regulated by the receptor activator of nuclear factor kappa-B (RANKL)/osteoprogeterin (OPG) pathway. These results suggest that GTE supplementation prevents severe postmenopausal bone loss by maintaining the regulation of bone homeostasis in OVX rats. GTE as a diet supplement might be a potential novel alternative for the prevention of postmenopausal osteoporosis. View Full-Text
Keywords: nutritional supplement; postmenopausal osteoporosis; bone homeostasis; green tomatoes nutritional supplement; postmenopausal osteoporosis; bone homeostasis; green tomatoes
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MDPI and ACS Style

Nirmala, F.S.; Lee, H.; Kim, J.-S.; Ha, T.; Jung, C.H.; Ahn, J. Green Tomato Extract Prevents Bone Loss in Ovariectomized Rats, a Model of Osteoporosis. Nutrients 2020, 12, 3210. https://doi.org/10.3390/nu12103210

AMA Style

Nirmala FS, Lee H, Kim J-S, Ha T, Jung CH, Ahn J. Green Tomato Extract Prevents Bone Loss in Ovariectomized Rats, a Model of Osteoporosis. Nutrients. 2020; 12(10):3210. https://doi.org/10.3390/nu12103210

Chicago/Turabian Style

Nirmala, Farida S., Hyunjung Lee, Ji-Sun Kim, Taeyoul Ha, Chang H. Jung, and Jiyun Ahn. 2020. "Green Tomato Extract Prevents Bone Loss in Ovariectomized Rats, a Model of Osteoporosis" Nutrients 12, no. 10: 3210. https://doi.org/10.3390/nu12103210

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