Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
1
Yale College, Yale University, New Haven, CT 06511, USA
2
Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06519, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3001; https://doi.org/10.3390/nu12103001
Received: 20 August 2020
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Revised: 25 September 2020
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Accepted: 26 September 2020
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Published: 30 September 2020
(This article belongs to the Special Issue The Impact of Vitamins, Minerals and Functional Foods on Bone Health)
Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main source of dietary phosphorus. Reduced bioavailability of Pi or excessive losses in the urine causes rickets and osteomalacia. While critical for health in normal amounts, dietary phosphorus is plentiful in the Western diet and is often added to foods as a preservative. This abundance of phosphorus may reduce longevity due to metabolic changes and tissue calcifications. In this review, we examine how dietary phosphorus is absorbed in the gut, current knowledge about Pi sensing, and endocrine regulation of Pi levels. Moreover, we also examine the roles of Pi in different tissues, the consequences of low and high dietary phosphorus in these tissues, and the implications for healthy aging.
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Keywords:
dietary phosphorus; inorganic phosphate (Pi); hypophosphatemia; hyperphosphatemia; mineralization; absorption; paracellular; transcellular
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MDPI and ACS Style
Serna, J.; Bergwitz, C. Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging. Nutrients 2020, 12, 3001. https://doi.org/10.3390/nu12103001
AMA Style
Serna J, Bergwitz C. Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging. Nutrients. 2020; 12(10):3001. https://doi.org/10.3390/nu12103001
Chicago/Turabian StyleSerna, Juan, and Clemens Bergwitz. 2020. "Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging" Nutrients 12, no. 10: 3001. https://doi.org/10.3390/nu12103001
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