Baked Bread Enhances the Immune Response and the Catabolism in the Human Body in Comparison with Steamed Bread
Abstract
:1. Introduction
2. Materials and Methods
2.1. Making Steamed Bread and Baked Bread
2.2. Volunteers
2.3. Treatments
2.4. Cytokine Network
2.4.1. Detection of Serum Cytokine Profiles
2.4.2. Construction of Cytokine Network
2.5. Central Metabolic Pathway (CMP) Metabolic Network
2.5.1. Construction of Metabolic Network
2.5.2. Determination of Serum Glucose and Lactate
2.5.3. Determination of Expression Levels of Metabolic Enzymes in CMP
2.6. Statistical Analysis
3. Results
3.1. Serum Cytokines Concentrations
3.2. Serum Metabolic Enzyme Expression Levels
3.3. Cytokine Network and CMP Metabolic Network
3.3.1. Cytokine Network
3.3.2. CMP Metabolic Network
3.3.3. Relationship Between the Cytokine and CMP Metabolic Network
4. Discussion
4.1. Baked Bread Enhanced the Immune Response as Compared with Steamed Bread
4.2. Baked Bread Increased the Catabolism and Decreased the Anabolism as Compared with Steamed Bread
4.3. Steamed Bread and Baked Bread May Affect the Secretion of Cytokines Which Regulate Metabolism
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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Intermediate Metabolites | Mass Balance Equations |
---|---|
Glucose-6-phosphate | X1 = r1 − r2 − r3 |
Glyceraldehyde-3-phosphate | X2 = r3 − r4 |
Pyruvate | X3 = r4 − r5 − r6 |
Acetyl Coenzyme A | X4 = r6 − r7 |
Immune Cells | Output/Input | Nonimmune Cells | Output/Input | Total Network Strength (St) | |||
---|---|---|---|---|---|---|---|
Nodes Strength 2 | Nodes Number | Nodes Strength 2 | Nodes Number | ||||
Steamed Bread | Th1 | 2.18/−2.15 | 15/23 | Fibroblast | −3.99/11.89 | 21/20 | 36.39 |
Th2 | 3.72/−6.65 | 15/22 | Hematopoietic stem cell | 0/11.83 | 0/15 | ||
Monocyte | 0.24/4.65 | 19/22 | Endothelial cell | −1.27/−7.20 | 18/15 | ||
Macrophage | 0.24/4.65 | 19/22 | Smooth muscle cell | 0.52/−5.15 | 19/8 | ||
Natural killer cell | −3.90/−2.11 | 16/19 | Osteoblast | 2.63/4.38 | 10/14 | ||
B cell | 0.24/−3.34 | 19/17 | Astrocyte | −5.12/−2.18 | 16/4 | ||
Neutrophil | −3.24/15.87 | 9/15 | Stromal cell | 2.70/0 | 14/0 | ||
Eosinophil | −0.12/4.27 | 12/23 | Thyroid cell | 0/−2.18 | 0/4 | ||
Basophil | 4.14/−6.86 | 14/18 | Epithelial cell | −0.09/−2.18 | 15/4 | ||
Dendritic cell | 0.33/10.10 | 18/13 | Synovial cell | 2.63/0 | 10/0 | ||
Mast cell | 5.36/−0.80 | 14/22 | Chondrocyte | 2.63/0 | 10/0 | ||
Cytotoxic T lymphocyte | 0/−11.21 | 0/13 | Adipocyte | 2.63/0 | 10/0 | ||
Microglia | 2.63/2.56 | 10/18 | |||||
Thymocyte | 3.09/0 | 12/0 | |||||
Baked Bread | Th1 | 6.31/2.60 | 14/10 | Fibroblast | 0/3.16 | 10/6 | 98.54 |
Th2 | 6.31/−4.5 | 12/6 | Hematopoietic stem cell | 0/3.16 | 0/6 | ||
Monocyte | 2.10/7.50 | 11/12 | Endothelial cell | 6.31/−0.07 | 12/12 | ||
Macrophage | 10.11/8.91 | 17/10 | Smooth muscle cell | 1.70/−4.5 | 4/6 | ||
Natural killer cell | 0/1.26 | 10/3 | Osteoblast | 0/3.16 | 0/6 | ||
B-cell | 2.10/−1.34 | 11/10 | Astrocyte | 0/1.28 | 0/3 | ||
Neutrophil | 0/8.91 | 0/10 | Stromal cell | 1.70/0 | 4/0 | ||
Eosinophil | 0/3.16 | 0/6 | Myoblast | 0/1.28 | 0/3 | ||
Basophil | 0/7.66 | 0/10 | |||||
Mast cell | 6.31/0 | 12/0 | |||||
Dendritic cell | 6.31/7.66 | 12/10 |
Items | Control | Steamed Bread | Baked Bread | |
---|---|---|---|---|
Serum collected at 14:30 | Glucose (mg/dL) | 89.14 ± 2.99 | 88.94 ± 2.46 | 87.67 ± 2.88 |
Lactate (mg/dL) | 22.76 ± 0.88 | 21.00 ± 0.85 | 24.63 ± 1.01 | |
NADH (mg/L) | 38.70 ± 7.29 | 69.26 ± 12.54 | 33.31 ± 6.23 | |
Serum collected at 15:30 | Glucose (mg/dL) | 91.78 ± 1.65 | 79.15 ± 1.61 | 84.29 ± 2.76 |
Lactate (mg/dL) | 19.57 ± 0.91 | 17.35 ± 0.82 | 17.73 ± 0.95 | |
NADH (mg/L) | 62.29 ± 9.40 | 53.73 ± 9.65 | 61.51 ± 8.55 |
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Wang, H.; Pang, G. Baked Bread Enhances the Immune Response and the Catabolism in the Human Body in Comparison with Steamed Bread. Nutrients 2020, 12, 1. https://doi.org/10.3390/nu12010001
Wang H, Pang G. Baked Bread Enhances the Immune Response and the Catabolism in the Human Body in Comparison with Steamed Bread. Nutrients. 2020; 12(1):1. https://doi.org/10.3390/nu12010001
Chicago/Turabian StyleWang, Huisong, and Guangchang Pang. 2020. "Baked Bread Enhances the Immune Response and the Catabolism in the Human Body in Comparison with Steamed Bread" Nutrients 12, no. 1: 1. https://doi.org/10.3390/nu12010001