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Nutrients
Volume 11
Issue 9
10.3390/nu11092014
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Article

Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring

by
Stefano Sartini
*,
Davide Lattanzi
,
Michael Di Palma
,
David Savelli
,
Silvia Eusebi
,
Piero Sestili
,
Riccardo Cuppini
and
Patrizia Ambrogini
Department of Biomolecular Sciences, University of Urbino Carlo Bo, I-61029 Urbino, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2014; https://doi.org/10.3390/nu11092014
Submission received: 24 July 2019 / Revised: 16 August 2019 / Accepted: 23 August 2019 / Published: 27 August 2019
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Abstract

Creatine plays a crucial role in developing the brain, so much that its genetic deficiency results in mental dysfunction and cognitive impairments. Moreover, creatine supplementation is currently under investigation as a preventive measure to protect the fetus against oxidative stress during difficult pregnancies. Although creatine use is considered safe, posing minimal risk to clinical health, we found an alteration in morpho-functional maturation of neurons when male rats were exposed to creatine loads during brain development. In particular, increased excitability and enhanced long-term potentiation (LTP) were observed in the hippocampal pyramidal neurons of weaning pups. Since these effects were observed a long time after creatine treatment had been terminated, long-lasting modifications persisting into adulthood were hypothesized. Such modifications were investigated in the present study using morphological, electrophysiological, and calcium imaging techniques applied to hippocampal Cornu Ammonis 1 (CA1) neurons of adult rats born from dams supplemented with creatine. When compared to age-matched controls, the treated adult offspring were found to retain enhanced neuron excitability and an improved LTP, the best-documented neuronal substrate for memory formation. While translating data from rats to humans does have limitations, our findings suggest that prenatal creatine supplementation could have positive effects on adult cognitive abilities.
Keywords: creatine supplementation; prenatal treatment; adult offspring; hippocampus; neuron excitability; long-term potentiation creatine supplementation; prenatal treatment; adult offspring; hippocampus; neuron excitability; long-term potentiation

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MDPI and ACS Style

Sartini, S.; Lattanzi, D.; Di Palma, M.; Savelli, D.; Eusebi, S.; Sestili, P.; Cuppini, R.; Ambrogini, P. Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring. Nutrients 2019, 11, 2014. https://doi.org/10.3390/nu11092014

AMA Style

Sartini S, Lattanzi D, Di Palma M, Savelli D, Eusebi S, Sestili P, Cuppini R, Ambrogini P. Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring. Nutrients. 2019; 11(9):2014. https://doi.org/10.3390/nu11092014

Chicago/Turabian Style

Sartini, Stefano, Davide Lattanzi, Michael Di Palma, David Savelli, Silvia Eusebi, Piero Sestili, Riccardo Cuppini, and Patrizia Ambrogini. 2019. "Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring" Nutrients 11, no. 9: 2014. https://doi.org/10.3390/nu11092014

APA Style

Sartini, S., Lattanzi, D., Di Palma, M., Savelli, D., Eusebi, S., Sestili, P., Cuppini, R., & Ambrogini, P. (2019). Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring. Nutrients, 11(9), 2014. https://doi.org/10.3390/nu11092014

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