High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential
by
Qiufen Mo 1,2, Aikun Fu 3, Lingli Deng 1,2,†, Minjie Zhao 1,2, Yang Li 1,2,‡, Hui Zhang 1,2 and Fengqin Feng 1,2,*
Qiufen Mo 1,2, Aikun Fu 3, Lingli Deng 1,2,†, Minjie Zhao 1,2, Yang Li 1,2,‡, Hui Zhang 1,2 and Fengqin Feng 1,2,*
1
College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang University, Hangzhou 310058, China
2
Ningbo Research Institute, Zhejiang University, Ningbo 315100, China
3
Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou 310064, China
*
Author to whom correspondence should be addressed.
†
Current address: College of Biological Science and Technology, Hubei Minzu University, Enshi 445000, China.
‡
Current address: School of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
Nutrients 2019, 11(9), 1981; https://doi.org/10.3390/nu11091981
Received: 28 July 2019 / Revised: 11 August 2019 / Accepted: 16 August 2019 / Published: 22 August 2019
Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of 400, 800 and 1600 mg kg−1 for 4 months, respectively. Results showed that supplementation of GML, regardless of the dosages, induced modest body weight gain without affecting epididymal/brown fat pad, lipid profiles and glycemic markers. A high dose of GML (1600 mg kg−1) showed positive impacts on the anti-inflammatory TGF-β1 and IL-22. GML modulated the indigenous microbiota in a dose-dependent manner. It was found that 400 and 800 mg kg−1 GML improved the richness of Barnesiella, whereas a high dosage of GML (1600 mg kg−1) significantly increased the relative abundances of Clostridium XIVa, Oscillibacter and Parasutterella. The present work indicated that GML could upregulate the favorable microbial taxa without inducing systemic inflammation and dysfunction of glucose and lipid metabolism.
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Keywords:
glycerol monolaurate; gut microbiota; metabolic dysfunction; barrier function; anti-inflammation
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MDPI and ACS Style
Mo, Q.; Fu, A.; Deng, L.; Zhao, M.; Li, Y.; Zhang, H.; Feng, F. High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential. Nutrients 2019, 11, 1981.
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