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The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity

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School of Food and Advanced Technology, Massey University, Palmerston North 4442, New Zealand
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School of Health Sciences, Massey University, Palmerston North 4442, New Zealand
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Riddet Centre of Research Excellence, Massey University, Palmerston North 4442, New Zealand
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Cawthron Institute, Nelson 7042, New Zealand
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Sanford Ltd., Auckland 1010, New Zealand
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Centre for Metabolic Health Research, Massey University, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1601; https://doi.org/10.3390/nu11071601
Received: 18 June 2019 / Revised: 9 July 2019 / Accepted: 11 July 2019 / Published: 15 July 2019
The prevalence of osteoarthritis (OA) is rising worldwide, with the most pronounced increase being in the category of metabolic-associated osteoarthritis (MetOA). This is predicted to worsen with the global rise in aging societies and obesity. To address this health burden, research is being conducted to identify foods that can reduce the incidence or severity of MetOA. Oil from the Greenshell mussel (Perna canaliculus) (GSM), a native New Zealand shellfish, has been successfully used to reduce OA symptoms. The current study assessed the effect of including flash-dried powder from whole GSM meat as part of a normal (control) versus high-fat/high-sugar (HFHS) diet for 13 weeks on the development of MetOA in rats. Rats fed a HFHS diet developed metabolic dysregulation and obesity with elevated plasma leptin and HbA1C concentrations. Visible damage to knee joint cartilage was minimal, but plasma levels of C telopeptide of type II collagen (CTX-II), a biomarker of cartilage degradation, were markedly higher in HFHS-fed rats compared to control-fed rats. However, rats fed the HFHS diet containing GSM had significantly reduced serum CTX-II. Inclusion of GSM in rats fed the control diet also lowered CTX-II. These findings suggest that dietary GSM can reduce the incidence or slow the progression of early MetOA. View Full-Text
Keywords: osteoarthritis; metabolic dysregulation; obesity; diet-induced obese rats; Greenshell mussel; Perna canaliculus osteoarthritis; metabolic dysregulation; obesity; diet-induced obese rats; Greenshell mussel; Perna canaliculus
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MDPI and ACS Style

Siriarchavatana, P.; Kruger, M.C.; Miller, M.R.; Tian, H.S.; Wolber, F.M. The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity. Nutrients 2019, 11, 1601. https://doi.org/10.3390/nu11071601

AMA Style

Siriarchavatana P, Kruger MC, Miller MR, Tian HS, Wolber FM. The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity. Nutrients. 2019; 11(7):1601. https://doi.org/10.3390/nu11071601

Chicago/Turabian Style

Siriarchavatana, Parkpoom; Kruger, Marlena C.; Miller, Matthew R.; Tian, Hong S.; Wolber, Frances M. 2019. "The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity" Nutrients 11, no. 7: 1601. https://doi.org/10.3390/nu11071601

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