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Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden
Department of Biochemistry and Molecular Cell Biology, University Medical Center; Hamburg-Eppendorf, 20246 Hamburg, Germany
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2019, 11(4), 852;
Received: 28 February 2019 / Revised: 9 April 2019 / Accepted: 10 April 2019 / Published: 15 April 2019
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The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in the regulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHA and low or high content of sucrose impact on metabolism in mice deficient for elongation of very long-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. We found that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, high fat challenge significantly increased body weight. This diet affected the triglyceride rich lipoprotein fraction of plasma lipoproteins and changed the expression of several genes involved in lipid metabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals is synergistically influenced by DHA dietary and sucrose content. View Full-Text
Keywords: DHA deficiency; ELOVL2; DHA supplementation; high sucrose diet DHA deficiency; ELOVL2; DHA supplementation; high sucrose diet

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Pauter, A.M.; Fischer, A.W.; Bengtsson, T.; Asadi, A.; Talamonti, E.; Jacobsson, A. Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice. Nutrients 2019, 11, 852.

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