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Nutrients 2019, 11(4), 836; https://doi.org/10.3390/nu11040836

Cynanchum wilfordii Etanolic Extract Controls Blood Cholesterol: A Double-blind, Randomized, Placebo-Controlled, Parallel Trial

1
Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Korea
2
Biodiversity Research Institute, Jeju Technopark, Seogwipo, Jeju 63608, Korea
3
Healthcare system Gangnam Center, Seoul National University Hospital, Seoul 06236, Korea
4
Department of Family Medicine, CHA Bundang Medical Center, Seongnam-si 13496, Korea
5
Department of Family Medicine, Seoul National University Hospital, Seoul 03080, Korea
*
Authors to whom correspondence should be addressed.
Received: 12 March 2019 / Revised: 6 April 2019 / Accepted: 10 April 2019 / Published: 12 April 2019
PDF [1428 KB, uploaded 12 April 2019]

Abstract

We evaluated the effects of Cynanchum wilfordii (CW) ethanolic extract on blood cholesterol levels in adults with high low-density lipoprotein cholesterol (LDL-C) levels. In a double-blind, randomized, placebo-controlled, parallel trial, 84 subjects were recruited. Participants were randomly divided into two groups with a low-dose (300 mg/d) or high-dose (600 mg/d) of CW. Levels of very low-density lipoprotein (p = 0.022) and triglycerides (p = 0.022) were significantly lower in the low-dose CW group than in the placebo group after 8 weeks. In a subgroup of participants with LDL-C≥ 150 mg/dL (n = 33), there was a significant decrease in total cholesterol (low-dose, p = 0.012; high-dose, p = 0.021), apolipoprotein B (low-dose, p = 0.022; high-dose, p = 0.016), and cholesteryl ester transfer protein (low-dose, p = 0.037; high-dose, p = 0.016) after 8 weeks of CW. The correlation between changes in total cholesterol and baseline LDL-C levels was significant in the groups that received both doses of CW (low-dose, p = 0.010; high-dose, p = 0.015). These results show that the CW ethanolic extract can regulate blood cholesterol in subjects with LDL-C≥ 150 mg/dL.
Keywords: blood cholesterol; clinical trial; Cynanchum wilfordii; LDL-cholesterol; hyperlipidemia blood cholesterol; clinical trial; Cynanchum wilfordii; LDL-cholesterol; hyperlipidemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Youn, J.S.; Ham, Y.M.; Yoon, W.-J.; Choi, H.-C.; Lee, J.E.; Cho, B.; Kim, J.Y. Cynanchum wilfordii Etanolic Extract Controls Blood Cholesterol: A Double-blind, Randomized, Placebo-Controlled, Parallel Trial. Nutrients 2019, 11, 836.

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