The Role of Muscle Decline in Type 2 Diabetes Development: A 5-Year Prospective Observational Cohort Study
AbstractThe major risk factors of T2DM (type 2 diabetes mellitus) development are still under investigation. We evaluate the possible risk factors associated with type 2 diabetes (T2DM) in adult subjects during a five-year prospective cohort study. We recruited 1160 subjects who underwent oral glucose tolerance test, anthropometric measurements, and body composition and body fat distribution analysis at a baseline visit and again at follow-up after approximately five years. The conclusions of this study are based on observation of 219 subjects who attended both the first and follow-up visits. The fasting serum insulin was measured, and HOMA-IR (homeostatic model assessment of insulin resistance) was calculated. During the follow-up period, T2DM was diagnosed in 7.4% of participants, impaired fasting glucose in 37.7%, and impaired glucose tolerance in 9.3%. Logistic regression models, adjusted for age, were constructed. The changes in glucose concentration, visceral fat tissue content, insulin resistance, and %loss of muscle mass were chosen as the potential predictors for T2DM development. A set of independent variables was extracted. The constructed feature set comprised change in HOMA-IR (OR (odds ratio) = 1.01, p < 0.01) and change in %loss of muscle mass (OR = 0.84, p < 0.03). With an aim to validate the prediction capability using the selected attributes, a support vector machine classifier and leave-one-out cross-validation procedure was applied, yielding 92.78% classification accuracy. Our results show the correlation between the %loss of muscle mass and T2DM development in adults, independent of changes in insulin resistance. View Full-Text
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Maliszewska, K.; Adamska-Patruno, E.; Goscik, J.; Lipinska, D.; Citko, A.; Krahel, A.; Miniewska, K.; Fiedorczuk, J.; Moroz, M.; Gorska, M.; Kretowski, A. The Role of Muscle Decline in Type 2 Diabetes Development: A 5-Year Prospective Observational Cohort Study. Nutrients 2019, 11, 834.
Maliszewska K, Adamska-Patruno E, Goscik J, Lipinska D, Citko A, Krahel A, Miniewska K, Fiedorczuk J, Moroz M, Gorska M, Kretowski A. The Role of Muscle Decline in Type 2 Diabetes Development: A 5-Year Prospective Observational Cohort Study. Nutrients. 2019; 11(4):834.Chicago/Turabian Style
Maliszewska, Katarzyna; Adamska-Patruno, Edyta; Goscik, Joanna; Lipinska, Danuta; Citko, Anna; Krahel, Aleksandra; Miniewska, Katarzyna; Fiedorczuk, Joanna; Moroz, Monika; Gorska, Maria; Kretowski, Adam. 2019. "The Role of Muscle Decline in Type 2 Diabetes Development: A 5-Year Prospective Observational Cohort Study." Nutrients 11, no. 4: 834.
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